drop in ALC during wait and watch

[venk_46]

I was dx cll in feb 2013 and still under wait and watch. no bad markers in Flowcytometry( negative for CD38 and Zap70 ) IGVH mutated, WBC/ ALC went up to 176,300/164,000 in March 2017 . In june 2017 my wbc/ALC is 114,300/108000. The other parameers like Hb @ 11.6, RBC 4.28 and platelets 134,000,

Lymph nodes in neck,abdomen enlarged , spleen 152 mm( same as since last 6 months . Is it usual to expect a substantial fall in WBC/ALC with out any treatmnet ? any problem with enlarged lymphnodes at a later stage if untreated now ? Any body in the group has a similar problem.

I am aged 71 years and live in India . There are not many CLL specialists here at my place

[BambinoDan]

Hello! May I say I'm very glad to read your post. Very similar situation here and I could not find one person with dropping WBC and ALC during watch and wait! I'm being told to start FCR treatment next week as my platelets have dropped in recent months. But I have Not been able to get a straight answer about the odd incident of dropping white blood cells without treatment. Do you have any updates? And insights? Thank you. I hope you are doing well!