My husband has PVD and now has such blocked arteries that he has no pulses in his legs. His heart failure is too severe for him to be considered for surgery but the pain in his legs is horrendous. I can hear him moaning and calling out in pain even as I write this. He has been given a prescription for Burpanorphine but is delaying taking them for as long as possible because of the possible reactions. Has anybody on here been prescribed these and how did you get on with them? It's so frightening hearing him in such pain and I just don't know how to help. Thank you so much for reading this.