Different test reports for HER2

[fighter123]

Dear all,

My mother 64 is diagnosed with breast cancer. MRM done. Biopys says

INVASIVE DUCT CARCINOMA, NOS, GRADE III,pSTAGE : pT2N0.

AXILLARY : 16 LYMPHNODES ISOLATED, ALL ARE FREE OF TUMOR. (0/16)

Her tumor was tested (post surgery) for ER, PR and Her2-neu at Rajiv Gandhi, Delhi and the report said triple negative (HER2 as 0).

We took blocks for second opinion to Balaji Action, Delhi and the reports says ER-ve, PR-ve but HER2-neu as 2 to 3+ (equivocal).

Confused now as HER2 plays an decisive role in deciding the treatment.

is any of the lab above not 'standard'. what should we do next? experts pls suggest.

[roxboxfox RadiationOncologist]

Speak to your Oncologist about the discrepant reports, he may suggest getting FISH analysis done on the specimen to get the Her 2 analysis. This will be the Gold standard, its an expensive test around 7-10K or so.

[Nikita1806]

Yes, her2+ plays an important role in deciding the treatment. There are targetd therapies available which can be used for her2+ patients.