I was prescribed "Serevent" (Salmeterol) to replace the maintreatment of "Tiotrupium" (Spiriva). The dose prescribed was 1 dose daily. It wasn't helping so I switched back to Tiotrupium, however closely reading the GSK Instructions for Salmeterol it clearly states "the normal starting dose is 2 puffs twice daily". I have recommenced with Salmeterol taking 1 puff twice daily at 12 hour intervals and so far it seems to be helping and I seem to need less Ventolin between times. Has anyone else experienced a similar situation.