Amlodipine

[Tinker2015]

When you stop Amlodipine how long does it stay in your system. I have read that it can take 12 days is this correct. Pharmacist said it has a half life 3/4 days so confused.

[MichaelJH Heart Star]

I was on Amlodipine for a period. When it was stopped the only thing I noticed was the odema it had caused started really going down after a couple of days. I believe its half life to be around 50 hours.

May I ask why you seem concerned about how long the last traces remain in your system?

[Tinker2015 in reply to MichaelJH]

Just been reading on the internet that’s all. It’s 12 days this Sunday since last one taken

[ILowe]

The half life usually varies considerably between individuals, and increases in old age. Some drugs have a narrow range of action, so as soon as you stop taking them you lose the effect. The usual rule of thumb though I think is 3-5 half lives. Fortunately, in your question I do not have to guess.

"Discontinuation of amlodipine treatment results in a slow return of blood pressure to baseline over 7-10 days, with no evidence of a 'rebound' effect." pubmed.ncbi.nlm.nih.gov/153...