I recently stopped taking Chinese Skullcap and have replaced that supplement with BroccoMax by Jarrow. This supplement is being heavily studied by scientists as a general anti-aging supplement and clinically as an anti-cancer agent. Human studies show that it does in fact reach the brain, and researchers at Johns Hopkins University list it as the single most important supplement that they recommend for general anti-aging. I had previously seen the famous YouTube video explaining the benefits of naturally occurring Sulforaphane found in great abundance in Broccoli Seed Sprouts, but didn't realize it was available in supplement form until earlier this month. Now after hours of research I feel I can point to the high lights.
1) Sulforaphane has many fantastic benefits, but for patients with ataxia the important role is as an enhancer of NrF2 which is an important protein essential to the cellular repair process.
2) The bioavailability in humans has now been extensively studied and the short answer is the absolute best method to take Sulforaphane is to grow your own Broccoli Sprouts and eat about 100g per day, BUT that is almost impossible for most of us so . . .
3) There are now some supplements available that have human clinical studies testing their bioavailability and purity, BUT there is one new supplement that comes from Germany and has not yet been clinically tested, but is MUCH cheaper than other forms and research from the producer indicates it has the highest bioavailability yet (except for the expensive version found in France.)
So, long story long I'm now taking 1 pill morning and night of Jarrow's BroccoMax.
Cheers,
Joe in NY
And as always here are some links with research supporting my comments:
Best Sulforaphane Supplements for Nrf2 Activation – Containing Glucoraphanin + Myrosinase - alivebynature.com/best-sulf...
Sulforaphane Benefits: How It Slows Aging, Fights Cancer & More - wellnessmama.com/346041/sul...
Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders - ncbi.nlm.nih.gov/pubmed/317...
Broccoli or Sulforaphane: Is It the Source or Dose That Matters? - ncbi.nlm.nih.gov/pmc/articl...
Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation - ncbi.nlm.nih.gov/pmc/articl...
But the real truth of my post is to recommend that you take all the supplements listed in this post: healthunlocked.com/ataxia-u...