Scientists identify protein that could serve as a therapeutic target in lung cancer.

[2greys]

Scientists at VCU Massey Cancer Center have identified a protein that operates in tandem with a specific genetic mutation to spur lung cancer growth and could serve as a therapeutic target to treat the disease.

Mutations in the p53 gene are found in more than half of all cancers, but it remains difficult to effectively target the gene with drugs even decades after its discovery. Though previous research has shown that p53 acts as a tumor suppressor and initiates cancer cell death in its natural state, a new study led by Sumitra Deb, Ph.D., suggests that gain-of-function (GOF) mutations — a type of mutation where the changed gene has an added function — turn p53 into an oncogene, causing cells to replicate uncontrollably and contribute to cancer development.

Recently published in Nature Communications, the researchers determined that mutant p53 genes are empowered by a specific protein, PLK3, to copy their genetic code and promote tumor cell proliferation through a process called transactivation.

Using preclinical models of lung cancer driven by p53 GOF mutations, Deb and his research team discovered that PLK3 activates an amino acid called serine 20 (S20), a cellular building block they found to play an important role in cancer cell replication.

masseycancercenter.org/news...

Nature Communications. Research Paper:

nature.com/articles/s41467-...

[Ergendl]

Wow! I find it so amazing, the detail these specialist scientists are uncovering about the biological chain of events in events like cancer development. Understanding what happens can then open doors onto new weaknesses in the chain that might be exploited by novel treatments.