Asthma: Calcium / CASRs, Sputum, Gallopamil

[Matman]

As many of you know, a primary 'mortality risk' with Asthma is 'fatal choking' resulting from Airway Sputum / Mucus. Not a particularly 'charming' way to Exit. (By the way, If you don't have time to read all of this - somewhat wordy - Post, please skip to my '2 Questions' near the end).

Airway Sputum is a particular interest of mine. Especially, how to prevent or minimise it.

Many Asthmatics who suffer from prominent Type 2 Asthma Inflammation, may well have symptoms that include 'breathing restrictions' due - or 'partly' due - to excessive Airway Sputum. (This 'might' also apply to other Asthma 'Types').

One theory concerning Sputum Production / Over Production (and how, perhaps, to reduce it) centres around Calcium Receptors. Note, this does 'not' necessarily imply that 'Dietary' Calcium is a contributor to Sputum / Mucus Production (and to Asthma Symptoms) although it's possible that some 'relationship' to dietary calcium (important for general health) may, in future, be identified. No rush just yet, however, to give up on 'Dairy' Produce.

There's a gap in my current knowledge concerning developments relating to Calcium Receptors / CASRs - i.e. what has happened since 2015 Research into 'Calcium Antagonists / Channel Blockers & Asthma' took place. This 'gap' includes a lack of knowledge of any subsequent research into the specific calcium antagonist / channel blocker 'Gallopamil', with respect to Asthma Treatment. (Particularly, that drug's 'potential' ability to reverse Airway Smooth Muscle Growth, which blights so many Asthma Suffers). Therefore, maybe someone can answer my Questions below.

QUESTIONS:

a) Has anyone been treated for Asthma with either Gallopamil, or any other drug that targets processes related to Calcium Receptors / CASRs?

b) Likewise, is anyone participating in a 'related' Drug Trial (and, if so, hows it working out for you)?

PS

If you're interest in some recent research that may have a bearing on this topic, I've provided a link (below) BUT the Article is not, primarily, aimed at the General Public, so is therefore somewhat 'technical'.

drugtargetreview.com/news/3...

Thanks in advance for any reply.

[Wheezycat]

What is ‘type 2 asthma’? I know of eosonophilic, late onset, allergic, non-allergic, but not type 2.

[Matman in reply to Wheezycat]

It's one of the prominent / primary Inflammatory Types used to Categorise, Group or Sub-Group Asthmatics. More details here:

ncbi.nlm.nih.gov/pmc/articl...

[Wheezycat in reply to Matman]

Thank you, Matman. I down loaded the article and read some of it, but as there is so much medical terminology, I haven’t yet got around the full meanings. I am still puzzled about this Thpe Two thing. I can see now what that means, but then there must also be type one etc, and that seems so far much harder to find - or have I yet not tried hard enough. Without that I could not even begin to pinpoint what I would fit. I am not asking you to provide the answer to this, but it does make me wonder how widespread that terminology and classification is?

[Nutzs47]

This is interesting as I get a very claggy throat with cold milk ,cheese etc even milk choc so avoid them as much as possible ,I haven’t drank cold milk for years, I don’t get it so much with low fat yoghurts though and hot milk doesn’t seem to have the same effect but I always put it down to lactose