changed time of taking Clopidogrel.

[Ladylovesmilktray]

Since starting to take Clopidogrel at night, alongside Atorvastatin, I noticed an increase in ectopic/irregular heartbeats.

I decided I had endured the anxiety associated with the symptoms long enough so am now taking Clopidogrel in the morning and my Atorvastatin in the evening. The result is…..a much calmer heart at night and a much better nights sleep.

when do most people take Clopidogrel and has anybody else experienced the symptoms I did? I’m

[Hullensian]

Cannot answer your question but will be following the answers you receive as my husband takes both of these - at the same time in the morning, along with Ramipril. However, your Pharmacist may be able to advise you.

[john-boy-92]

Clopidogrel is metabolised by the CYP2C19 enzyme that has a number of variants (allele). These can cause it to be metabolised between ultra-rapidly and poorly. Around 30% of white people have at least one variant, and this rises to 50% to 60% in Asian groups. The same enzyme also metabolises other medications such as omprazole, diazapam, and selective selatonin reuptake inhibitors. There are tests available for those variants. A paper by Bristol University (Bristol Technological Assessment Group) "Clopidogrel genotype testing after ischaemic stroke or transient ischaemic attack" describes the tests.