Minoryx launch phase 2/3 for new AMN drug

[wilburlois15]

Something else! Not exactly sure what it does because no description in the article (or anywhere else for that matter) but good news nonetheless.

aldlife.org/latest-news/min...

[monkeybus]

MIN-102, a PPAR Gamma agonist, differentiated PPAR Gamma agonist.

From our good friend Wikipedia...

PPAR-gamma agonists

PPARγ (gamma) is the main target of the drug class of thiazolidinediones (TZDs), used in diabetes mellitus and other diseases that feature insulin resistance. It is also mildly activated by certain NSAIDs (such as ibuprofen) and indoles, as well as from a number of natural compounds. Known inhibitors include the experimental agent GW-9662.

They are also used in treating hyperlipidaemia in atherosclerosis. Here they act by increasing the expression of ABCA1, which transports extra-hepatic cholesterol into HDL. Increased uptake and excretion from the liver therefore follows.

Animal studies have shown their possible role in amelioration of pulmonary inflammation, especially in asthma.

They increase the expression of ABCA1 (it says here), maybe they do the same for ABCD2/3.

I was looking at something the other day.

ncbi.nlm.nih.gov/pmc/articl...

A lot of PBAR's mentioned in that article. If I only knew what a PBAR was.

[monkeybus in reply to monkeybus]

And this one is much more readable.

sciencedirect.com/science/a...

Have a good read of that if you have a spare hour to kill. Lists plenty of naturally occurring PBAR agonists.

I note that Cannabis Sativa is listed (I don't smoke it any more, but I'd have another shot at it).

[monkeybus in reply to monkeybus]

Final link, highly readable...

diabetesselfmanagement.com/...

Nice find, wilburlois15

[monkeybus in reply to monkeybus]

Really the final link.

Pioglitazone was patented for the treatment of our disease back in 2013.

google.com/patents/US8865747

Pioglitazone, a PBAR agonist.

Wouldn't surprise me that, like Biotin being renamed MD1003, this could just be an existing medicine repurposed for us.

I've a lot of these patents bookmarked, all promising a cure for us.

I'll post them up later.

Here ends my final post.

[nan17 in reply to monkeybus]

Hi Monkey,

Just read a substantial portion of google.com/patents/US8865747 and understood bits and pieces of it. Thanks for posting this. It's helpful to see some of what is going on research-wise. I got some ideas about questions to ask my doc and maybe thoughts about antioxidant treatments coming up.

We can only keep our fingers crossed. At least they work ;-).

Nan17