Reducing oxidative stress and inflammation to fight neurodegenerative diseases

[wriga]

I normally post on the Parkinson's disease forum because I have PD , but I believe this post is equally relevant for Alzheimer's disease

I am a research scientist, now retired. This is the subject I've been working on for a 18 months now. The basic research has been going on for 20 years. The key researchers are the brilliant Prof Albena Dinkova-Kostova in Dundee UK for the cellular and genetic processes, the neuroscientist Antonio Cuadrado in Madrid and Jed Fahey in US for plant chemistry. They all work together. I've been mostly working with Albena, but I'm now working withJed Fahey. The science is now established and mature. Oxidative stress and inflammation are a common problem of people who have neurologal diseases and it increases with age. It causes damage to cell membranes and mitochondria. The system which should control excessive oxidation becomes deregulated as we gat older. We now know why and how to reset it using chemicals which attract electrons called electrophiles. You find these in food and the best is a substance called sulforaphane can be made from broccoli seeds. To resolve established oxidative stress you need high concentration which you get only in seeds and young sprouts. To get a good yield a very specific extraction process needs to be strictly followed. The choice of seeds and the dose is also critical. When you get it right it works, at least for me and for a small group of PD patients who have used it.

After 12 months of experimentation I now feel it is ok to tell this story more widely.

The file below is an introduction for non-scientists. It is posted on blog I recently set up which has several pages and other material.

At the end of that article is a link to a long scientific article with references to the underlying research.

patientresearcher.com/2021/...