Been on Pradaxa since 2016. Seems to do the job, but having started on 150mg found that bleeding from the anus was very unpleasant. The doctor reduced the dose to 110mg and that solved the problem. Taking the tablet gave me a lot of wind, but drinking plenty of water solved that.
Pradaxa terrifies dentists and most will not even do a filling while taking it. Recently had a biopsy in hospital and they would not touch me unless I had stopped taking Pradaxa for three days.
I cannot say that Pradaxa has made me put on weight, but even at 82 I play tennis twice a week and go to the gym regularly. Regular exercise is recommended and if permitted by the doctor you should get out of breath at least four times a week with a minimum of five hours of medium intensity training or sport. This keeps the weight down.
When I first started with Pradaxa I noticed that my VO2 rating slipped as if the blood could not carry the oxygen as well as it did, but this recovered slowly, but not completely. I get the impression that Pradaxa and the Q10 that the heart needs do not go together well, but I am not medically qualified.