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Apixiban

sugaredalmonds profile image
79 Replies

Good morning all,

For years I have taken Eliquis apixiban, 5mg twice a day, yesterday I collected my prescription, only opened it this morning & I have for the first time been given Teva apixiban, different brand, same dose.

Have to admit, feeling a little nervous taking a different brand as I have never had any problems with the Eliquis . Am I over thinking & worrying unnecessary?

It doesn’t help that I have also been given a higher dose of BP meds ( 10mg twice a day Lercanidipine), which is making me nervous.

Any thoughts anyone?

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sugaredalmonds
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79 Replies
TamlaMotown profile image
TamlaMotown

Hi sugaredalmonds, (my mam loved those sweets)I felt exactly as you but I've had no problems at all.

I've taken Teva & Sandoz for quite a while now.

sugaredalmonds profile image
sugaredalmonds in reply to TamlaMotown

Hi, ok thank you.

Samazeuilh2 profile image
Samazeuilh2 in reply to TamlaMotown

I must admit that I had never heard of Teva Apixaban before I read your post. I will have to check that I have not been given it. I’m guessing it’s a cost-saving measure. Are there any known differences between Teva and Eliquis in terms of medical properties, safety etc..

Della71 profile image
Della71 in reply to Samazeuilh2

Teva is the pharmaceutical company as is Sandoz. Same drug, different manufacturer.

BobD profile image
BobDVolunteer

To be honest I have no idea what brand of anything I get given. I merely fill my 7 day pill box each week and the rest wait in a cupboard. Then again I never read the "what if" sheets with the pills and never have any side effects.

sugaredalmonds profile image
sugaredalmonds in reply to BobD

Hi, thank you, I admire your attitude, will try to take a leaf from your book.

Singwell profile image
Singwell in reply to sugaredalmonds

I've been given the Teva now too and no issues.

gtkelly profile image
gtkelly in reply to BobD

Same here. As long as the generics have the required chemical ingredient I’m thankful that I can get it. Anyway, after 4 years no issues with whatever brand they given me. Thankfully.

reinaway profile image
reinaway in reply to BobD

Well you don't know how lucky you are Bob. I'm OK with most of my drugs but have terrible stomach problems with the BB Nebivolol that I take and put it down to the different fillers that the Manufacturers use. I can only tolerate certain brands.

BobD profile image
BobDVolunteer in reply to reinaway

I know from the shape of the tablets that I have at least three different types of Nebivolol and never noticed any problems.

FancyPants54 profile image
FancyPants54 in reply to BobD

Nebivolol brands change all the time. I’ve not had an issue with that. But I won’t have brand changes for thyroid hormones.

Singwell profile image
Singwell in reply to reinaway

I found similar issues when on Flecainide. The only one thT worked well for me was Accord. Yes I've changed my brand of Diltiazem twice and had no problems...

frazeej profile image
frazeej in reply to BobD

Same here.

JimF

mhoam profile image
mhoam

I have taken both Eliquis and generic Apixaban (Teva) over the last year or so and have not noticed any difference.

good luck

sugaredalmonds profile image
sugaredalmonds in reply to mhoam

Hi, thank you too

Finvola profile image
Finvola

I always preferred the same brand too - until lockdown - when I received various brands, depending on supply. As the chemist delivers our drugs I felt it was safer to take what I was given than to risk COVID going to the chemist to 'sort it out'. I've had no problems with brand changing - including generics recently.

sugaredalmonds profile image
sugaredalmonds in reply to Finvola

Hi,

Thank you.

doodle68 profile image
doodle68

Hi , I have been taking Teva Apixaban for some time with no problems. I was told the previous suppliers of Apixaban became very expensive so it was a case of accept a new supplier or change to a different NOAC as happened to some people on here.

I preferred to stay with Apixaban .

sugaredalmonds profile image
sugaredalmonds in reply to doodle68

Hi,

Thank you,

CDreamer profile image
CDreamer

Apixaban is one Med I have no problems with switching brands with. At the moment I think it’s whatever brand is available - the generics are a lot cheaper than the brands normally.

Cost of Apixaban had biggest cost jump for NHS - quote:-

Apixaban was the drug with the highest costs of £430 million.

Apixaban 5mg tablets was the presentation with the largest increase in cost since 2021/22, with an absolute increase of £280 million.

nhsbsa.nhs.uk/statistical-c....

Rather staggering numbers.

sugaredalmonds profile image
sugaredalmonds in reply to CDreamer

Hi,

Thank you.

Singwell profile image
Singwell in reply to CDreamer

Blimey

opal11uk profile image
opal11uk

Change of brand is normally because the new are cheaper but should be no different in ingredients from the original.

FindingCaradoc profile image
FindingCaradoc

My brand has recently changed from Eliquis as well and I’ve not noticed any difference-not even sure what the brand is now -can’t see Teva on the packet and the PIL has gone in the recycling (I have read previous versions 😂) - my current Apixaban is manufactured by Glenmark

iohnl profile image
iohnl in reply to FindingCaradoc

Same with me, no problems.

Ducky2003 profile image
Ducky2003

I got changed from Elquis to Sandoz brand about 3 months ago and haven't noticed anything different. The key ingredients will be the same but sometimes it's the fillers that cause reactions. I have to have Sandoz for one of my eye drops as another brand caused an issue.

JOY2THEWORLD49 profile image
JOY2THEWORLD49 in reply to Ducky2003

Hi

I have POLY-Gel as I have no fluid layer so 4 times a day prescribed by Eye Specialist. 4 times a day for life.

No carrying around a bottle which needs keeping cold.

I rip off a strip.

No preservative in this item.

Hope this helps.

cheri JOY. 74. (NZ)

Ducky2003 profile image
Ducky2003 in reply to JOY2THEWORLD49

My drops are for ocular hypertension so only drops available or laser surgery, which I'm having next week. 😊.

JOY2THEWORLD49 profile image
JOY2THEWORLD49 in reply to Ducky2003

Hi

OK I wish you best wishes.

I wasn't aware that one can have laser for glaucoma.

My Mum had cataracts done one at a time than lasering for the

scarring as a result.

I hope that someone is in there to hold your hand.

I was for my MUM and dark glasses a must - the wrap around ones.

cheri JOY

Ducky2003 profile image
Ducky2003 in reply to JOY2THEWORLD49

Thanks. I don't have glaucoma, just ocular hypertension. 😊.

JOY2THEWORLD49 profile image
JOY2THEWORLD49 in reply to Ducky2003

Hi

My daughter adopted had laser treatment for her long distant trouble, I said not to. Because at an older age I can still read the paper with light

and I'm told the best long distant vision for a person over 60.

It wasn't called hypertension but a similar word .. one for the length of the ....

Now I don't need specs for driving or looking long distant.

Actually I have one long and one short distant eyes!!!!!!

So one helps the other in bringing together optimum vision. Hypo........

I had worn specs since I was 12 but as folks get older the short vision goes.

At 30 my daughter's eyes became early short sightedness.

cheers JOY

Glaucoma is pressure build up in the eye. If left untreated one could lose their sight.

JOY2THEWORLD49 profile image
JOY2THEWORLD49 in reply to Ducky2003

Hi again

I am learning.

Mine and my adopted daughter had myopia.

But I see your diagnosis.

I read that without meds - e.g. drops glaucoma can develop and that is why you need to be monitored closely.

What does the laser do?

cheri JOY

Ducky2003 profile image
Ducky2003 in reply to JOY2THEWORLD49

Glaucoma is damage to the optic nerve which can be caused by pressure building up but high pressure doesn't always lead to glaucoma. They keep an eye on me (no pun intended) just in case.The laser surgery is called a selective laser trabeculoplasty (SLT). It lasers away part of the mesh at the rear of the eye which is supposed to help with drainage. It works in some people but not with everyone. They also have no way of knowing who it will work for in advance . There's about a 65-70% chance of it working.

JOY2THEWORLD49 profile image
JOY2THEWORLD49 in reply to Ducky2003

Hi

Oh Heck.

It is your eye sight.

Trouble is laser it can set up scar tissue.

Do make sure that you see an eye even optometrist regularly.

Can you feel it building up?

Has it anything to do with hypertension causing trouble with your heart?

cheri JOY. Thinking of you, sending prayers for the success of the procedure.

Ducky2003 profile image
Ducky2003 in reply to JOY2THEWORLD49

I have hospital appointments every 3-4 months so being monitored. No, never feel a thing whether pressure high or low.

I don't have hypertension with my heart. My blood pressure is normal. The ocular hypertension has nothing to do with blood pressure or the heart.

It's supposed to be a 3-5 minute procedure.

Thank you for your good wishes. 😊

JOY2THEWORLD49 profile image
JOY2THEWORLD49 in reply to Ducky2003

Hi

But I guess you will have an injection in your eye first.

Will the surgeon do one eye or two.

With Mum's catarrahs one eye at a time. At 90! I have been told that I have these developing as well.

The Government are going to change things to fund them.

Here in NZ no more prescription fee! It got to $5 each line. With Synthroid 2 x $5 as it comes in a 100 and 25 for me. However when I got to $100 free - no more prescription fee to pay.

Sad about the CAPSULE UNDER WATER USA MADE when NZ said NOT SAFE. A bit like the White Island ERUPTION when we NZders knew it was going blow sometime. Some flew there, hovered in the sky and flew back.

Now we have a PROPERTY AGENT missing now changed to a homocide.

What next after global heat over there and here wide spreading flooding. My house insurance rose $400. With no threat of flooding, earthquake or sunamni here on my property of 33 years! I used to be able to insure house and 2 vehicles under $1000.

Rates up EWD Earthquake and War Damage have risen within that price by $150.

The talk about lifting 15%GST off vegetables and fruit is appetising to my ear.

Changed car to automatic little 1.3L Sporty Yaris when my 99 Galant only owner was stolen and with its messed up ignition, AA wrote it off. Boo HOO.

Have your moan too. Our elections are coming up in October which I put my hand up for the last 5 times.

cheri JOY. 74. (NZ)

pusillanimous profile image
pusillanimous

I've always been given Pfizer Eliquis

Ppiman profile image
Ppiman

Generic tablets are all essentially identical, formulated and tested to the same pharmacopeial standards. What can also be said is that Teva is a large and well-respected pharmaceutical manufacturing company with a long and good reputation. I feel sure that you will not notice the change; indeed, it's not impossible both tablets originated in the same factory and were tested in the same laboratory since my experience of generic manufacturing is that it is a strange area of manufacturing and selling.

Steve

JOY2THEWORLD49 profile image
JOY2THEWORLD49 in reply to Ppiman

Hi

You are talking about tablets

but

I got a rash on the side of my left foot. I was given the athlete's foot ointment.

It hurt applying it. I continued going through all the generic pharmac founded ointments.

It did not improve. Then I was told to ask a foot clitician.

She made a list.

One not funded by pharmac proved excellent. It cost me $25, it did not make the rash sore, it seemed to 'glad wrap' the area. Then eventually the whole area stripped off like a second skin.

Its never returned and I use it for athlete's foot which I can get once or twice a year.

But I'm told the main ingredient is the same.

It's magic.

cheri JOY. 74. (NZ)

The husband had athlete's foot and after a surgery to remove a cyst, I got into his gumboots with a bandage but I got caught out somehow.

Ppiman profile image
Ppiman in reply to JOY2THEWORLD49

What an interesting story, Joy. What cream are you using? We get Athlete's Foot now and again and always use something called terbinafine cream. I've never found anything that keeps it away, though. Sadly, I have ingrown toe nails and the fungus got into them - another difficult thing to remove. My toes would never win a beauty contest! ;-)

Steve

JOY2THEWORLD49 profile image
JOY2THEWORLD49 in reply to Ppiman

Hi

It starts with D.. I had better do some searching.

There is a new strength available now. I can see the tube white with blue advertising.

I will get back to you all.

But always oil your feet, including in between each of your toes.

Ingrowing toe nails - here's my tip.

PUT A V in the middle of nail. It prevents ingrowing because it takes time to FILL IN the V and forgets to grow into the sides.

So cut straight across first, then go back and V it. Keep this up.

I have never continued to have an ingrowing toe nail.

cheers JOY.

gtkelly profile image
gtkelly in reply to JOY2THEWORLD49

Wow! That’s a new type of foot specialist I’ve never heard of. That foot rash musta spread quite a long way up your leg?!

JOY2THEWORLD49 profile image
JOY2THEWORLD49 in reply to gtkelly

Hi

No.

Just along the inside of foot. It was red and itchy. But all the other ointments made it very sore.

A total different place to under foot.

I did need antibiotics with the cyst lesion.

It had piles of stitches. I had to have gas taking them out. I hate folks touching my feet.

Unfortunately there was a mist of plaster in the air due to casts being sawed off.

cheers JOY

gtkelly profile image
gtkelly in reply to JOY2THEWORLD49

Sorry. Misread. Thought you said you’d seen a clitician.

Ppiman profile image
Ppiman in reply to JOY2THEWORLD49

I’ve enjoyed this rather extended thread!

Steve

JOY2THEWORLD49 profile image
JOY2THEWORLD49 in reply to Ppiman

Hi

Life is learning and we can't have that what is left in life!

Im trying to search for my ointment whilst doing lots of clearing to my land.

cheri JOY

RAS54 profile image
RAS54 in reply to Ppiman

I agree Steve. I once had a position in a generic pharmaceutical manufacture looking after the retained batch samples. Many different brands are made on same production line. the packaging changes but tablets are all same. So you may have Teva, Accord, Kent, Milpharm, Mylan, Cresent etc all made on same day by one manufacturer. Check the PL number on packet. PL stands for product License Number if it's the same on different brands it is exactly the same.

Ppiman profile image
Ppiman in reply to RAS54

Yes - it was a while back that I learned this but think things are more complicated than ever today. The PL license is the key.

Steve

sugaredalmonds profile image
sugaredalmonds in reply to RAS54

Interesting

OldJane profile image
OldJane

I’ve had two different brands of Apixaban as well as eliquis. No problems at all. Some may as different “fillers” if so go back to doc and argue for original. As I have no problems I’m happy for the health service to save a little on an expensive medication

sugaredalmonds profile image
sugaredalmonds in reply to OldJane

Hi

Ok thank you

Tangalle profile image
Tangalle

Morning sugaredalmonds, I don’t take Axipan but had the brand of 2 of my medications changed recently. Like you I was concerned as different brands use different fillers which potentially can cause problems for some people. I asked my GP to put the name of the brand on my prescription, which was done and no brand issues since. Worth a try if you are still concerned. Best wishes

sugaredalmonds profile image
sugaredalmonds in reply to Tangalle

Hi

Ok thank you

It is no surprise that many doctors are having to find alternatives to drugs in an effort to reduce costs.

Apixaban is made solely by Pfizer and Bristol Myers who have just won an extension of 20 years to stop other manufacturers making this drug.

Apixaban slows down the livers ability to make the clotting factor Xa… other drugs from other manufacturers can do this equally as well but somehow everyone believe Pfizer is the best manufacturer… I beg to differ.. they just have a better marketing strategy.. tell people long enough you are the best and you get top dollar and the biggest share of the market.

This removes competition and keeps the price per tablet high.

Most drugs eventually lose their exclusivity and the method to produce gets released on the open market thereby reducing the price per tablet.

Pfizer are run by very clever marketers… it’s all about money… it always was.

sugaredalmonds profile image
sugaredalmonds in reply to

Hi

Thank you

frazeej profile image
frazeej in reply to

>>it’s all about money… it always was.<<. I believe this is called capitalism.

in reply to frazeej

I call it greed…but if you want to stick with communism counters be my guest.

flecathletics profile image
flecathletics in reply to

For clarification Pfizer/BMS have retained sole rights to market apixiban in the US (but just for another three years) whereas they do not now have sole rights in Europe (i. e. the patents have expired effectively) hence the fact that Teva and others can now sell their own apixiban in the U.K.

in reply to flecathletics

Thanks I did realise that must of occurred because of these “other” brands… but felt more against the tactics used in initial marketing.. money seems to be more important than helping people live longer.

Cavalierrubie profile image
Cavalierrubie

I have had many different brands of drugs with no adverse reactions. They change the brand name, but contents cannot be changed. Think about it, we would all be very ill if we were not getting the correct medication.

sugaredalmonds profile image
sugaredalmonds in reply to Cavalierrubie

Hi

Ok thank you

momist profile image
momist

I think I've had five different brands so far, from my pharmacist. They seems to be shopping around for the cheapest/most available every time afresh. Teva is the most common one. I'm currently on Glenmark, but my next pack is Teva again.

sugaredalmonds profile image
sugaredalmonds in reply to momist

Hi

Thank you, clearly from all the kind responses I have really worried for nothing.

JOY2THEWORLD49 profile image
JOY2THEWORLD49

Hi Sugared Almonds!

I'm sure you would like the MAGNUM 3 PKT Non Dairy Almond's on a stick!

I picked another packet today.

I chose PRADAXA 110mg twice daily as it has an antidote.

There is always the risk of taking it twice or forgetting it.

Not sure why your Dr has put up your dose of BP meds. He should have discussed it with you. Honestly I would ? before changing your dosage in case wrong or different patient.

But its usual to be tested at every 3 month intervals . BP and H/R.

Drs would only up my meds so the Locum suggested a great private Heart Specialist. He introduced CCB Calcium Channel blocker which took my H/R down 105 bpm in 2 hours! It was 1/2 dose.

So working with Diltiazem CCB and BB Bisoprolol with Healthline and NZ Heart Foundation I arrived at

120mg Diltiazem AM and 2.5mg (reduced from 10mg) Bisoprolol PM BBs weren't controlling my H/Rate.

I manage my Health and with information and ?s answered by Dr/Specialist I have

got to a place of control and improvement.

After 1 year on CCH my H/R tumbled some more - it could be 3-5kg weight loss of

126/69. 62 climbing to 69 H/R Day.

I only just controlled enough to undergo my operation last March 2022 to remove Johnson & J Sling Kit. It was 88-96.

I ended up with 2 anaesthetists in the room.

What is your BP and H/R? Have you had a 24-monitor on the meds you are on previously.

In 2021 I had 3 x heart 24 hr monitors with existing then on each change e.g. Metoprolol, then Bisoprolol and lastly Diltiazem with a lesser dosage of Bisoprolol.

It is important to check on how your heart is coping with changes.

Simply putting up meds doesn't always solve the problem.

Take care and try those choco non dairy almond icecream on a stick - surprise yourself.

What you are saying is very confusing.

cheri. JOY. 74. (NZ)

sugaredalmonds profile image
sugaredalmonds in reply to JOY2THEWORLD49

Hi

Thank you

Dorchen profile image
Dorchen

Hi , mine was changed to Teva , not aware of any difference or problems ( fingers crossed) xx

sugaredalmonds profile image
sugaredalmonds in reply to Dorchen

Hi

Thank you

Clarrie profile image
Clarrie

I felt like you so asked my GP if I could have Eliquis as I had taken it for over 8 years with no problems and this is now specified on my prescription.

sugaredalmonds profile image
sugaredalmonds in reply to Clarrie

Hi

Ok thank you

2learn profile image
2learn

hi, I take 6 pills for different conditions and over the years the brand name and packaging changes frequently. Pharmacists say drug is the same, but there can be a change in the transporter used to get the drug into your body, this may cause a short term side effect such as feeling giddy or sick but it usually only lasts for about a wk until your body gets used to something new.

MWIC profile image
MWIC

same here - always eliquis until the last couple of months and getting a different brand each time - not noticed anything so far so all seems Ok

BlueMonday67 profile image
BlueMonday67

Hi, Over the last few months have had 3 different makes of apixiban.No problems at all. I assume rightly or wrongly they all have the same ingredients.it's just that the original licence has expired so any pharmaceutical company can now make them.

Kibuli profile image
Kibuli

No need to worry its just a change in brand ..will be exactly the same 👍

Qualipop profile image
Qualipop

I react really badly to a lot of the generics but the one brand I've never had problems with is Teva

kitttycat profile image
kitttycat

Hello as a precaution its a good idea to have your information at the drugstore inidcate the brand of medicine you take, because it can make a difference. It happened to me, with something and a change made me severely dizzy- I couldnt take it.

Buzby62 profile image
Buzby62

There’s been a few posts about this in the last few months, I read somewhere that other manufacturers were not allowed to sell the generic versions before a change in the licence or patent that happened about 6 months or so ago, prior to that lots of GPs were trying to get patients to change to a completely different drug to save cost of branded apixaban. I’ve only had Teva and Sandoz in the last 6 months and can’t say I notice the difference. I’m happy to have the generic versions rather than change to a different drug all together.

Do a search on this site for “apixaban change” and you should find plenty of posts and replies to put your mind at rest.

DiyChas profile image
DiyChas

It looks like a generic version is now valid. If correct, the price per pill will drop dramatically.

I understand apixaban to be about $300/mo (5mg/pill, 60/mo) to our govt.

Visigoth profile image
Visigoth

I’ve had 3 or 4 different brands after having Eliquis and have never noticed any difference at all. The same is true of my other medications.

JOY2THEWORLD49 profile image
JOY2THEWORLD49

Hi

Bisoprolol has changed packaging but remains the same look - easy to divide if your dosage is for 1/2.

Diltiazem became ACCORD when the original one unavailable. But I knew only because the colour changed!!!!!

Then i asked the Chemist.

I prefer 90 tablets/caps in a sealed container with an expiry date of manufacture.

Like thryroxine Synthroid. Much more reliable.

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