Comparing Effectiveness of Anticoagulants

[MJZaw]

I previously posted a link to an article regarding stroke risk and anticoagulants. Here is a link to more recent research (May 2020) Comparing Effectiveness of Anticoagulants

pcori.org/sites/default/fil...

[Ppiman]

I find it hard to find worthwhile studies that meaningfully compare DOAC drugs, and in the few I have found, apixaban seems to be more effective than rivaroxaban, despite this latter drug being the preferred one in the UK, which surely suggests that it is sufficiently or equally effective.

Have you found anything useful comparing the two?

Steve

[MJZaw in reply to Ppiman]

I suspect there is anecdotal "evidence" out there that supports different approaches, some of which might be provided by drug companies. However, this is the most recent science-based research I could find.

[Hidden]

Thanks for posting the article. I've just started taking Apixaban so it's useful.

[JuliaJa]

Could you post the link to the first article?

[jwsonoma]

Thanks a very interesting study.

I think Wafarin results suffer from infrequent testing. I saw this as part of a wafarin compliance study: "Only 26% of patients taking warfarin had stable INR values over a 6-month period; just 34% continued to have stable results in the subsequent year, whereas 36% had 1 or more extreme INR values."

The study's definition of a stable INR was being in the INR "Zone" 80% of the time.

jamanetwork.com/journals/ja...

I would prefer to switch to a DOAC but my Doctor wants me to tightly control my INR because I ski and mountain bike. I self test every 3-4 days to stay in the "Zone".

I could be reading too much into the study but it doesn't bode well for those DOACs that are only "as good as" wafarin if wafarin has such poor compliance.

With all that testing I am still only in compliance 90% of the time.

It is a pain to est all the time but, reading between the lines, I am inclined to stay on Wafarin regardless of sports.