Lansoprazole and Warfarin: Following a TIA... - AF Association

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Lansoprazole and Warfarin

AFHenz
AFHenz

Following a TIA earlier this year I was initially prescribed Lansoprazole which is I understand a Proton Pump Inhibitor (PPI), along with Clopidrogel until further investigation showed that I had PAF, since the end of April I have been taken off Clopidrogel and given the options of Warfarin or one of the other more recent Anticoagulants like Rivaroxaban that are now available, I chose Warfarin and am currently trying to maintain an acceptable INR reading. Relating to the use of PPI's which I understand are given to some heart patients to counter the effects of some antiplatelet medication such as Clopidrogel raises a question for me, as I was speaking to someone (a pharmacist) a couple of days ago who suggested that the long term taking of Lansoprozole should maybe be questioned with anti coagulation drugs because of their association with a reduction in calcium absorption ..... My question is - are there any other members taking Warfarin who are also on Lansoprozole or is this a possible oversight when medications changed which I may need to question when I next see the doctor? Any comments would be appreciated ....

10 Replies
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BobD
BobDVolunteer

PPIs long term ARE a bad idea. The lower sphincter of the stomach needs an acid environment to open so if you reduce the acid there is a danger that food remains there longer than it should and that reflux may be increased.

There is no known requirement for a ppi with warfarin so you decide. WE should not give advice on drugs or dosage as we are not medically trained . Hope that helps.

AFHenz
AFHenz
in reply to BobD

Thanks for your response Bob, the more I read about PPI's the more reluctant I am to take, particularly as I have never suffered GERD or similar. I appreciate your comments on advice and agree wholeheartedly, but was interested from a personal point of view whether others had been moved off Lansoprazole after stopping Clopidrogel ....

Hi AFHenx - I had a very strong reaction to your post as I believe that we are prescribed too many pills too easily and for no good reason which often make us more ill - and PPI’s are in that category for me - along with statins.

I have been prescribed a PPI on more than one occasion to counteract symptoms for more than several drugs - before I had even had any symptoms ?!! - and never, ever taken one, nor needed them.

IMHO very, very overprescribed and more often than not, not required and should never be used for more than a few weeks. In the case of taking asprin or an antipoatelet - maybe for protecting against increased risk of stomach bleeds - when taken daily.

Do have acid reflex?

I don’t take Wafarin but Apixaban - DOAC. And neither are anti-platelets? What was the reason to take PPI in the first place?

AFHenz
AFHenz
in reply to CDreamer

First of all thank you for your prompt reply which completely supports my own views. I am still very new to this drug thing having been a non tablet taker for most of my life (now 68). Having had the TIA before a diagnosis of AFib (which does seem to be the opposite to others on the Forum I have read about, trust me to be different) .... I can only assume that the PPI was given pre diagnosis to accompany the initial Clopidrogel TIA treatment in hospital until ECG monitor results were known and passed to GP. I have never suffered from acid reflux and generally maintained acidity (in my mind at least) with a glass of warm water and freshly squeezed lemon. I have stopped the daily lemon juice by the way in case it interacts with other medication ....

CDreamer
CDreamer
in reply to AFHenz

I am pretty sure you are ok with lemon juice but you can check with your pharmacist - it’s grapefruit or the juice that interacts with quite a few meds

Hidden
Hidden

I have been taking lansoprazole alongside warfarin for a number of years.

I was prescribed this following an upper endoscopy. It has helped greatly with acid reflux which I'm afraid can occur with me by simply drinking too much water before sleeping !

I certainly wouldn't take this unless I had to .

Thank you for taking the time to share your own experience, I can fully understand your reasoning given the help it has given you. All I am trying to do is get things sorted in my own mind as to why I am still prescribed Lansoprozole when I have never suffered reflux and am no longer on Clopidrogel ....

I think you are right to query this,I had a TIA in November and had to take 300 mg aspirin for a week.At the time I was not on anticoagulant,despite being known AF patient.How ever,4 days later I was back home ,cameramen to A and E with chest pain,......outcome was OFF aspirin and onto apixaban,and flecanaide.

I suspect it may be miscommunication or an oversight,and would definitely check it out.

best wishes

Thanks for your response and information. I am at the INR Clinic this afternoon, so will certainly query ....

AFHenz
AFHenz
in reply to AFHenz

Just an update .... I have now been told that I can drop the Lansaprozole after raising the issue and my concerns. Thanks to all for your comments and support 👍

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