This appeared in my email from Medscape. It was one in the case challenge
Below is the bottom line
NOACs for Atrial Fibrillation: Important Drug/Drug Interactions
What is the take-home message from drug interactions with NOACs? I think the most important thing to remember is the drug amiodarone. Amiodarone is often used in patients with atrial fibrillation, the condition that is the most common indication for a NOAC. If possible, use of amiodarone in patients who are on NOACs should be avoided.
It is important to remember that warfarin also has a potentially significant interaction with amiodarone as well. The difference is that it is easier to measure the drug interaction with warfarin—that is, you can serially measure the international normalized ratio and adjust the dose of warfarin as needed. This is much harder to do with NOACs. There may be a role for continued use of warfarin in patients who must be on amiodarone or dronedarone.