New here, had AF couple of years. I read others have problems with low heart rate and tiredness on bisoprolol. Dr said it helps symptoms but does not prevent events. I have tried to cut down on my already low dose but always seems to set off the AF quite soon. Just wondered if any experience to share about when best to take it. I take it first thing each day, probably because I was told to. The majority of my more severe incidents seem to occur in the night or I wake with it. A bit concerned about taking at night because I find very low heart rates a bit scarry and the happen over night.