Hi I have had PAF for the past 3 years and take bisoprolol 2.5 mg morning and 1.25mg at night together with Apixaban 5mg twice daily . Does anyone have symptoms of feeling extremely cold especially late afternoon . My resting pulse never goes above 50 bpm and at times 45 bpm ar rest . I also get out of breath even walking short distances. My cardiologist suggested taking Flecainide instead of bisoprolol . I tried this for I month but I could not tolerate the side effects.