Anyone had any bad experiences when taking Bisoprolol? I have been taking it for 6 years now and it has been fine up until now. It feels as if I may be toxic,very sleepy in the morning after taking it, feeling my head shift, have had to go to bed, after 12.00 absolutely fine. I have been taking 3.75 for a year, this morning I have taken 2.50, still the same feeling and heart rhythm uncontrolled. I have an appointment with my GP today in the evening.