I`ve been on Pradaxa for 5 months and after a very dodgy first 3 months think my body is getting used to it (my bowels aren`t yet though). Havent had blood test for kidneys as it seems should be done but going to GP Monday and will ask him about that. What I would value your thoughts on is that with warfarin there are regular checks to make sure the dose is right but with Apixaban, Pradaxa etc there isn`t. I was thinking that maybe you can have too much or not enough (i`m on 150mg twice a day). Do the docs ever check this ? Saw the Cardiologist on Tuesday, said I have a slightly leaky valve and make appointment for I think she said `Valve Cleaning` clinic - she was Russian with a very think accent so it was difficult.