After a-fib unable to be controlled by meds, decided on ablation after several ER visits for high H.R. uncontrolled by cardizem. Put on Xeralto for 5 weeks prior to ablation. After 2 weeks on Xeralto, had new and worsening leg, back and shoulder pain. By 5th week had such severe pain could not dress myself or drive. Immediately after ablation got off Xeralto and went to Warfarin. Leg pain improved but shoulder pain continues. I have no previous history of shoulder pain and no trauma to my shoulders. Had cortisone shot in shoulder which gave short term 2-3 day relief. Now will begin physical therapy to try to improve shoulder pain which is severe enough that it is difficult to sleep at night. If you have osteoarthritis symptoms on any of these new anticoagulant drugs, I suggest you get off immediately and go to Warfarin before you develop long term muscular problems. Fortunately, my a-fib is resolving and I am not having any flutter after 3 weeks post-op.