Targeted Chemo Treatment Trial?

[jackwfrench]

My MO says work on treating individual tumors with targeted chemo vs. full body treatment is happening- anyone familiar?

[NanoMRI]

I discussed this few years back and recently with my singularly identified melanoma liver met.

The bigger question - what if the targeted tumor is not all of the cancer? What of additional unidentified tumors, micromets, cancer stem, senescent cells, etc?

For my prostate cancer pelvic mets I chose surgery. For my melanoma, immunotherapy.

[God_Loves_Me in reply to NanoMRI]

Tall_Allen - Learning questions. How do you address this questions ?

"What of additional unidentified tumors, micromets, cancer stem, senescent cells, etc?"

When doctor or clinical trial focus is treat only PMSA expressed tumors ?

[Tall_Allen in reply to God_Loves_Me]

There are many investigational targets beyond PSMA - STEAP1, FAPI, hK2...

[God_Loves_Me]

Yes I was enrolled in ARX517 that's combinations of Chemo + Immunotherapy that target all PSMA expressed tumors. I happy with result

[Tall_Allen]

This trial had good but not great results:

pubmed.ncbi.nlm.nih.gov/299...

Here are some lab studies:

sciencedirect.com/science/a...

pmc.ncbi.nlm.nih.gov/articl...

pubs.acs.org/doi/abs/10.102...

journals.plos.org/plosone/a...

pmc.ncbi.nlm.nih.gov/articl...

sciencedirect.com/science/a...

tandfonline.com/doi/full/10...

pubs.rsc.org/en/content/art...

pmc.ncbi.nlm.nih.gov/articl...

pmc.ncbi.nlm.nih.gov/articl...

[jackwfrench in reply to Tall_Allen]

Thanks this is what I was hoping for- i am nadir and just one nasty met on the hip

[Tall_Allen in reply to jackwfrench]

You can only detect one nasty met on the hip. Targeted chemo is far from ready for prime time, I'm afraid.

[GP24]

I think your MO is refering to antibody-drug conjugates (ADCs)

google.com/url?sa=t&source=...