Darolutamide monotherapy?

[Mike1971]

I’m on Enzalutamide (Xtandi) monotherapy at the moment which seems to work fine and the side effects are manageable (I work out pretty hard almost every day to keep them abay). I still have some libido and I still “function” somewhat in bed with some help, but would do anything to increase my libido as it’s very important to my QoL.

I’ve read Darolutamide (Nubeqa) doesn’t pass the blood-brain barrier and therefore doesn’t affect libido as much, so I plan to talk to my doctor and ask if switching to Darolutamide monotherapy instead would be a possibility for me.

Anyone here on Darolutamide monotherapy?

[Chipichape1]

I am 74 and on Nubeqa ( Darolutamide) with Leuprolide and I was considering stopping both in 3 months after 1 year on it if my PSA continues undetectable.

Interesting to hear that you have some libido when the Nubeqa drops the testosterone to almost zero,

And that is what drives the libido. Strange.

[dhccpa in reply to Chipichape1]

He's on Xtandi now.

[Mike1971 in reply to Chipichape1]

Hi Chipichapel1,

I still had libido (although very lowered) when I was on Lupron + Zytiga for two years. Now on Xtandi, which doesn’t affect me as much (yet at least), but I’m still interested to see if there are even “better” alternatives, hence my question about Darolutamide.

[petrig in reply to Chipichape1]

Nubeqa does not drop testosterone.Nubeqa works to block the effects of testosterone from reaching cancer cells. It belongs to a class of medicines called androgen receptor blockers, also known as anti-androgens.

[85745]

I am on orgovyx and nubeqa took the peanuts out of my M&M 's. But I 'm alive . Once in a while the soldier uniforms up and stands at attention. lol

[Mike1971 in reply to 85745]

👍😀

[Leonardo556]

After three years of monotherapy, I changed bicalutamide to darolutamide. After next half a year, I added a small dose of Orgovyx, which increased the effectiveness of monotherapy and solved the problem of gynecomastia.

healthunlocked.com/advanced...

[dhccpa in reply to Leonardo556]

Orgovyx solved it after you had gynecomastia? Was it bad at all or just starting?

[Leonardo556 in reply to dhccpa]

I had not gynecomastia because of radiation on brest 3x5 Gy. Howewer I had brest tenderness. Nubeqa double your testosteron. Low dose of Orgovyx can reduce , normalize level of testosteron.

[dhccpa]

How long have you been on Xtandi monotherapy? And we're you ever on ADT (Lupron, etc.) at all?

[Mike1971 in reply to dhccpa]

Hi dhccpa,

I’ve just been on Xtandi for a little more than four months - after a year of no treatments. Before that I was on Lupron and Zytiga for two years.

[dhccpa in reply to Mike1971]

Thanks. I'm looking at monotherapy after 6+ years of Lupron only.

[Mike1971 in reply to dhccpa]

Thx. What monotherapy will you do?

[dhccpa in reply to Mike1971]

Probably Xtandi or Nubeqa.

[Mjex]

I tried to switch from Erleada to Nebequa (Apalutamide to Darolutamide and couldn't get insurance to cover it because it is not approved for use in Hormone Sensitive PC unless you have taken or are taking docataxel. The cost without coverage was over $16,000 a month.

[Mike1971 in reply to Mjex]

Mjex, I’m sorry. I wish treatment costs shouldn’t be an issue for anyone in our situation.

[j-o-h-n in reply to Mjex]

to Mjex,

No no no. The letter U does not follow the letter Q in Nubeqa but it does follow the Letter N instead of the letter E. And the words "Big Bucks" follow the word Nubeqa.

Enjoy 2025.

Good Luck, Good Health and Good Humor.

j-o-h-n