APALUTAMIDE

[shappos]

I am taking apalutamide plus lupron but my psa is rising from .25 to .73 in 9 months and I have 3mets 2 lymph nodes and one in clavicle. Why does no one talk about apalutamide on this site?

[Researcher50]

Try searching the Brand Name Erleada

[GP24]

You can search for discussions regarding Apalutamide in this forum. This query retrieves 306 posts:

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[SteveTheJ]

You're wrong. This medication is mentioned constantly.

[EchoII]

see if you can get Darolutimide and Orgovyx instead. That combination works for me with less side effects

[dhccpa in reply to EchoII]

What had you tried beforehand that you're comparing them to? Thanks

[EchoII in reply to dhccpa]

Zytiga

[dhccpa in reply to EchoII]

Did you take Lupron before Orgovyx?

[EchoII in reply to dhccpa]

Yes. Bot my oncologist switched me

[VictoryPC in reply to EchoII]

Totally agree. Especially at 80.

[icanwintwice]

People talk about apalutimide all the time. Most are using Zytiga. The Stampede study was based on Zytiga, and Zytiga is now generic. It crushed my liver or I would have been on it for the two years I was prescribed Apalutamide. I had two mets in my lower lymph nodes and I am in remission for now and off of the drug. It looks like the drug is not working for you. I would talk to my doctor about alternatives.....

[shappos in reply to icanwintwice]

Thanks for replying.I have a telephone appointment with my consultant next week and by then we shall see what my new psa number is.Some or the treatments discussed on this sight are too expensive to be offered to me on the NHS IN Britain and she said to me 3months ago that .75 is very low and is ok although it had tripled.

[icanwintwice in reply to shappos]

there are a multitude of options out there for you. Keep the faith. You have my prayer Shappos!

[shappos in reply to icanwintwice]

Thank you

[VictoryPC in reply to icanwintwice]

Personally I found it to be a bridge to resistance. Just my opinion.

[speranza10]

It seems that the drug is losing its effectiveness. However, the growth of PSA alone does not demonstrate its failure but there must be a visible progression with scans.

[Carplake]

I started Lupron, 3month injection on 4/25/22 and had the normal side effects, heat flashes, sluggish. On 1/31/24 I had a Orchiectomy and stopped the Lupron. At 83 years of age the loss of sex was not a problem for me. I was also on high dose vitamin C.

[j-o-h-n]

Cause it's a tongue twister.... (Have a good 2025).

Good Luck, Good Health and Good Humor.

j-o-h-n

[MateoBeach]

The question is whether you should continue on Lupron with apalutamide and your PSA is indicating progression. Calls for a reassessment and change of therapeutic plan. Request a PSMA PET scan to see if mets are progressing and whether they are targetable by SBRT. Change to another hormone treatment may be needed to replace the apalutamide: darolutamide or abiraterone? Try testing response to BAT? Need for chemo to get it under control? Good luck. MB

[shappos in reply to MateoBeach]

Thanks for replying.Just had blood test so will find out next week what's going on will probably need another scan as I have had pain in right side of neck for many weeks.

[Eieio in reply to MateoBeach]

I concur 100% tumor burden will be high if you have not treated the Mets with SBRT. Lowering circulatory Pca Cells makes sense in the big picture. PMSA pet scan and don’t guess and demand a better response than just saying PSA isn’t that bad. It’s not a full indicator but an accurate barometer if you ask for more blood work to track circulatory markers and cell volumes. Also did you do genetic testing to see if a parp inhibitor , or targeted therapy could be layered on.

[Godsheal]

Couldn’t personally suggest anything different than the other reply’s except ask God for guidance. Prayers🙏