Revolutionary technology: transforming cancer cells into normal cells

[samill]

Good evening (or good morning): let's keep hope, if not for future generations.

Happy New Year. Cheers to you all!

Tuoi Tre Journal

27/12/2024

Researchers have developed a revolutionary new technique that can revert some cancer cells to a state similar to that of normal cells without killing them.

By IFLScience page December 26, this is not only a potential new treatment for cancer, but also helps patients avoid the side effects of other treatments and the risk of drug resistance.

Cancer reversal, which reverts cancer cells to a differentiated, non-malignant state, has been proposed as a potential new treatment in recent times. Cancer cells are often "undifferentiated," meaning they do not have the properties or characteristics of normal cells.

According to the Wiki page, in developmental biology, cellular differentiation is the process by which a cell changes from one type of cell to another. Most commonly, the cell changes into a more specialized type.

IFLScience stated that by re-expressing differentiation-related genes, scientists can help reactivate them and restore their normal function, or even achieve “transdifferentiation,” where cancer cells differentiate into completely different cell types. For example, breast cancer cells are transformed into more specialized liver cells.

Previous studies have demonstrated the reversal of cancer cells associated with myeloid leukemia, breast cancer, and hepatocellular carcinoma (a type of liver cancer). However, researchers have not yet been able to systematically identify the specific genes or proteins that control the differentiation process that drives this type of differentiation/transdifferentiation. This is an important step that helps scientists manipulate and reprogram cancer cells to become non-cancerous cells.

In their latest research, Professor Kwang Hyun Cho’s team from the Department of Biological and Brain Engineering at the Korea Advanced Institute of Science and Technology (KAIST) has demonstrated a new technology that can convert colon cancer cells into normal cells.

Specifically, they developed a technology to create digital copies of the gene networks involved in a cell’s normal differentiation trajectory. Through this simulation, they were able to systematically identify the key components that drive normal differentiation.

The research team successfully applied this technology to colon cancer cells, helping the cells return to their normal state.

This work shows that it is possible to reverse the cancerous state of cells by creating and analyzing digital copies of the cancer cells’ gene networks. This work has the potential to pave the way for new reversible cancer therapies that can be used for many different types of cancer cells.

“The fact that cancer cells can transform into normal cells is an amazing phenomenon. This study demonstrates that such a reversal can be systematically generated,” said Dr. Kwang Hyun Cho.

The study was published in the journal Advancing Science.

Source: tuoitre.vn/cong-nghe-dot-ph...

Envoyer des commentaires

[pjd55d]

wow - I am always open to the possibility of advances... miracles

Happy New Year

[j-o-h-n]

Thanks for the information, and now if they can only convert French to English automatically.....("Sacré bleu") Happy New Year.

Good Luck, Good Health and Good Humor.

j-o-h-n

[32Percenter]

Dr. Jean Caron was able to demonstrate this effect in the late 90s with breast cancer using methylsulfone (AKA methylsulfonylmethane or MSM). MSM turned metastatic breast cancer cells back into normal cells.

The in vivo protocol she suggested based on her research involves using 20-30g of MSM per day. This high dose of sulphur would make one's body odor and breath pretty bad, but who cares if it works?

Interesting (but not surprising) that a pharma company is working on a drug to do what a commonly-available supplement has already been shown to do. You can't patent a naturally-occurring compound, so some wheel-reinvention is needed I suppose.

[jazj in reply to 32Percenter]

But it's now the 2020's and MSM as far as I know isn't a cure for Breast Cancer. This demonstrates that it is often not possible to mimic what you can do in a laboratory, but in a human body instead. Not trying to be a Negative Nellie, but I can't begin to try to count the number of in-vitro studies I've read from 4-40 years ago that never amounted to anything significant regarding better treatment of humans with cancer.