Can oligometastatic prostate cancer b... - Advanced Prostate...

Advanced Prostate Cancer

22,348 members28,109 posts

Can oligometastatic prostate cancer be ‘cured’ with ‘total therapy’? This paper suggests there is a sliver of hope.

Broccoli24 profile image
5 Replies

Read the paper linked below for the full scoop… but it seems very positive indeed for a certain subset

Praful Ravi at Dana Farber asks…

Can oligometastatic prostate cancer be cured with ‘total therapy’? Check out our paper reporting on outcomes after fixed-duration ADT +/- ARPI, met-directed therapy and local therapy (if de novo) for omHSPC

At a median of 3yrs after completing a median of 2yrs of systemic therapy, 45% of patients remained progression free and off therapy. Median time to resume therapy was 4yrs. Hint at potential durable long-term remission (and possible cure) with this approach.

Supports ongoing deintensification trials in selected mHSPC patients who achieve an excellent response to therapy, and future trials need to explore fixed-duration therapy in this space. @AtishChoudhury @DanaFarber_GU @DanaFarberNews

sciencedirect.com/science/a...

Written by
Broccoli24 profile image
Broccoli24
To view profiles and participate in discussions please or .
Read more about...
5 Replies
kainasar profile image
kainasar

Did this study mention radiographic free survival in comparison to PFS?

Broccoli24 profile image
Broccoli24 in reply tokainasar

It cites PFS

KMY28 profile image
KMY28

Thank you for sharing. This is my exact situation. Recently diagnosed as T3bN2M1b oligometastatic. When we first learned of the 2 bone mets, we were devastated and thought there was no hope. Then met with both Dr. Mark Scholz and my oncologist who both used the word "curative." We said we thought that wasn't an option, but they both explained that, especially at my young age, an aggressive triplet approach (ADT, brachy therapy, SBRT, then docetaxel) there is an "excellent chance at a cure" even though it is late stage. So I am clinging to this sliver of hope for a possible cure at best, and long-term remission at worst.

bean1008 profile image
bean1008

My treatment included three PSMA PET scans, two surgeries and ADT. First surgery in 2017 to remove the prostate and anything visibly affected. Then a second surgery two years later to remove lymph nodes spotted in a second PSMA scan. A rising PSA in late 2020 lead to starting ‘doublet’ therapy…new at the time…of Lupron and abiraterone. The third PSMA scan was in January of this year that showed that the bone met in my hip socket was gone and there was no evidence of cancer. For now I appear to be cancer free and am off all meds! Checkups every four months. I feel that PSMA PET scans saved my life and were so important in my treatment decisions. Early in my treatment they were not covered by insurance but it was thousands of dollars well spent.

Wgly profile image
Wgly

Why can’t this be used fo omCSPC?

Not what you're looking for?

You may also like...

Local therapy in patients with newly diagnosed oligometastatic prostate cancer

New meta-analysis below. My radical prostatectomy of 12 years ago would not have occurred if there...
pjoshea13 profile image

Predictors of duration of Zytiga in men with CRPC.

New Dana-Farber / Sloan Kettering study [1] below. Not a lot of cases - 161. "All had received...
pjoshea13 profile image

Is there an "oligometastatic state" for prostate cancer?

Many of us have seen youtube videos making unsubstantiated claims about SBRT (or SABR) for...
Tall_Allen profile image

ASCO 2019: Outcomes of Men with Recurrent M0 Prostate Cancer who Defer Androgen Deprivation Therapy until Metastasis

"This abstract retrospective reviews 2,636 men who had radical prostatectomy between 1981 and 2017...
George71 profile image

Docetaxel timing in CRPC patients who had a poor response on ADT.

Interesting new paper from Japan. "We identified 148 mCRPC patients who were treated with 75 mg/m2...
pjoshea13 profile image