Just Out - Phase 2 Trial Researchers discover why taking a mushroom supplement slows or prevents prostate cancer from getting worse

[jazj]

Something to keep an eye on.

medicalxpress.com/news/2024...

"City of Hope researchers are now focusing on whether the reduction in MDSCs is associated with improved clinical outcomes in patients with prostate cancer."

[KocoPr]

just so you know it’s the water extract Agaricus bisporus.

Here is a 2022 article on WBM extract against PCa.

pmc.ncbi.nlm.nih.gov/articl...

White Button Mushroom (Agaricus bisporus) Disrupts Androgen Receptor Signaling in Human Prostate Cancer Cells and Patient-Derived Xenograft

[Tall_Allen]

Not a Phase 2 trial result. Just a press release.

[cesanon in reply to Tall_Allen]

Actually something more than a press release. But a really small sample of human subjects.

They call it a phase II , but it does seem like something less

"Focusing on eight participants',..."

medicalxpress.com/news/2024...

Looking at preclinical and preliminary human data, the City of Hope scientists found that taking white button mushroom pills reduces a class of immune cells called myeloid-derived suppressor cells (MDSCs), which has been linked to cancer development and spread.

"City of Hope researchers are investigating foods like white button mushroom, grape seed extract, pomegranate, blueberries and ripe purple berries called Jamun for their potential medicinal properties. We're finding that plant-derived substances may one day be used to support traditional cancer treatment and prevention practices," said Shiuan Chen, Ph.D., the Lester M. and Irene C. Finkelstein Chair in Biology, professor and chair of the Department of Cancer Biology and Molecular Medicine at Beckman Research Institute of City of Hope, and senior author of the new Clinical and Translational Medicine study.

"This study suggests that 'food as medicine' treatments could eventually become normal, evidence-based cancer care that is recommended for everyone touched by cancer."

The researchers profiled blood draws from some of the men participating in City of Hope's phase 2 clinical trial. The men were under active surveillance as they took white button mushroom supplements.

Focusing on eight participants' samples before and after three months of white button mushroom treatment, the scientists found that there were less tumor-creating MDSCs and more anti-tumor T and natural killer cells, suggesting white button mushroom rebuilds anti-cancer immune defense and slows cancer growth.

"Our study emphasizes the importance of seeking professional guidance to ensure safety and to avoid self-prescribing supplements without consulting a health care provider," said Xiaoqiang Wang, M.D., Ph.D., City of Hope staff scientist and first author of the study.

"Some people are buying mushroom products or extract online, but these are not FDA-approved. While our research has promising early results, the study is ongoing. That said, it couldn't hurt if people wanted to add more fresh white button mushrooms to their everyday diet."

City of Hope researchers are now focusing on whether the reduction in MDSCs is associated with improved clinical outcomes in patients with prostate cancer.

[Tall_Allen in reply to cesanon]

No, it's a press release.

They are recruiting for a Phase 2 trial which won't have results for another year.

clinicaltrials.gov/study/NC...

The press release is just making a big deal of the lab results that are showing an immune modulatory effect which is common but usually leads to nothing, I'm sorry to say.

[TC007 in reply to Tall_Allen]

Always Believe this guy because he knows more than researchers!

[j-o-h-n]

Mushroom ice cream (two scoops)....test it on your ex-wife first....

Good Luck, Good Health and good Humor.

j-o-h-n

[KarkMuzio in reply to j-o-h-n]

yes, testing everything on your ex wife...

[j-o-h-n]

Birds of a feather.......etc.

Good Luck, Good Health and good Humor.

j-o-h-n