My hubby has had 5 Docetaxel infusions. His PSA dropped significantly after first 2 infusions and started rising by a point or two before the 4. & 5th infusions.
Should we just stop since he seems to have reached the most it is going to do?
He has CDK12 mutation and research shows Nothing that is sustainable to stop its growth. Or at least that’s how it appears to me.
Please request to for PSMA PET SCAN and CT SCAN. I hope scan will tell you more and help you to decide whether to stop or not.
He may want to switch to cabazitaxel and look at imaging instead of just PSA to determine if chemo is successful or not.
There are a number of clinical trials for CDK12.
BTW, I love you for all you do for others.
I had twelve docetaxel infusions and it failed. I switched to cabazitaxel and carboplatin. Now my PSA is 0,08.
For all cancer patients,
God Bless Us, Everyone
Thank you for your response!
Were your side effects similar as with the Docetaxel???
I looked for your bio…. May I ask you a couple questions?
What was your PSA pre Docetaxel? And do you have any mutations?
What treatments pre Docetaxel did you have?
Thank you for a response !
Tall_Allen is your best source on this site. I fully support any advice he gives you.
My side effects were less with cabazitaxel and carboplatin. I slept for 4 hours afterward. With docetaxel, I slept for 7 hours.
Tom were you or would you been able to drive yourself after each treatment. Thanks
I could have driven myself a few miles, but I was drowsy. A friend accompanied me.
Thanks.
Why not have the full 6 cycles of docetaxel.
Pre-docetaxel my PSA was around 20. I have a PCa tumor in my liver.
That should be fatal.
After docetaxel I was put on cabazitaxel and carboplatin, but be careful,
that is a Hail Mary and last resort.
Before docetaxel, I had a lot of Androgen Deprivation Therapy (ADT).
I am being treated by Dana-Farber, among best in the world. They tell
my local clinic what to do. If you can get a similar arrangement with a big
center, go for it.
Tall_Allen is your best source on this site. I fully support any advice he gives you.
We see Dr. Aggarwal at UCSF…. And he actually dropped the ball with repeated clear PSMA scans and a rising PSA. Tall Allen is the reason I Insisted on a CT scan…. And sure enough …. Mets to lymphs in peritoneal abdominal lymphs! We could have gotten “on it” so much sooner …. But, He is a Good and highly sought after PC Oncologist, but definitely missed it on this one!
My husband (as of June) has no visceral or organ spread. He has had many “Gene/DNA” tests.
Boston Gene, Foundation One, Sage Medic,, Exact Sciences and Signatura.
He also is very involved With Patient Cancer Lab.
We live in Dallas and have a really skilled “Research” oncologist here also.
We will be going soon after his 6th infusion with Docetaxel to UCSF for SBRT …. AFTER he has another Axcuim and FDG scan.
We are covering all bases…. His CDK12 mutation is pretty much treatment resistant…
Clinical trials with Immunotherapy will be after SBRT.
You didn’t ask for all that… but, you are welcome anyway!🤣🤣🤣🤣🤣🤣🤣🤣🤣
Your husband is truly fortunate to have your help. My wife wants no part of this. Just notify her when it is over.
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