Post-Treatment Recovery and PSA Levels: Seeking Guidance After SBRT and ADT

[SierraSix]

68-Year-Old with Localized Gleason 9 (4+5)

Diagnosis: September 2022

Treatment Plan: 18 months of Lupron (started October 2022) and five sessions of SBRT, completed in December 2022.

Current Status: Took my last Lupron shot in January 2024. Just had a blood test yesterday (PSA and testosterone).

Latest Results:

• PSA: 0.02 (previously undetectable)

• Testosterone: 151 (up from 8 in the last 3 months)

It’s been about 6–7 months since my testosterone has started to recover after my last Lupron shot. I’m not scheduled to see my Radiation Oncologist until December, when I’ll also have another blood test and my 2nd-year MRI.

Additional Context:

• I’m getting a DEXA scan today to compare with the one I had when I first started ADT.

• I’ve lost over 10 pounds and continue to lift weights, run, and eat a healthy diet.

Questions:

• Do these numbers seem on track for a favorable outcome?

• Is there anything else I should be doing at this stage?

• Can anyone share studies or info on PSA levels post-radiation/ADT? I understand PSA can fluctuate. Is the typical post-treatment PSA range between 0.02 and 0.2?

Trying to educate myself on what to expect in the next phase of recovery and cancer treatment. Any advice or resources would be greatly appreciated!

Thanks,

Mark

[Justfor_]

They look good, but too early to definitely tell. To be more precise, they don't look worysome.

[MarkS]

As your nadir PSA after treatment was <0.06, it looks as though your prognosis is good. See:

ncbi.nlm.nih.gov/pmc/articl... "Nadir PSA is a strong predictor of treatment outcome in intermediate and high risk localized prostate cancer patients treated by definitive external beam radiotherapy and androgen deprivation"