Prednisone alternative for Glaucoma patients

[akaipop3ps]

Not sure if this has been posted before.

For those with Glaucoma, Prednisone may not be good for you. For steroid responders, Prednisone can increase your Intra Ocular Pressure leading to more damage to your retina fiber, losing more of your vision. It is advisable to discuss steroid use with both your ophthalmologist and your oncologist before you start using Prednisone. I do not know if there are alternatives to Prednisone (to be taken with Zytiga) or not.

Also not sure

[tango65]

Eplerenone is a drug which blocks the receptors for aldosterone, the only hormone produced by the suprarenal glands when taking abiraterone,

The increase in aldosterone production because an increase in ACTH during abiraterone treatment leads to sodium retention, water retention , edema, hypertension and hypokalemia.

To avoid this complication, prednisone is given to reduce the production of ACTH and concomitant the production of aldosterone,.

If prednisone or dexamethasone can't be used, eplerenone at high doses could be used to block the aldosterone. Eplerenone could be substituted by spironolactone if a longer acting drug is needed.

This approach has been already used and even published,

ncbi.nlm.nih.gov/pmc/articl...

[Tall_Allen]

The prednisone taken with Zytiga is merely a replacement dose to compensate for the lost cortisol. It should not affect your glaucoma.

[lgutman]

My dad (81) has glaucoma in both eyes, no vision in one, limited in the other. Due to this his second drug was Xtandi but this only worked for 4 months ( he was originally diagnosed with stage 4 Mets to ( plus bones.) His eye doctor has told us we can use steroids with this next treatment (going to arbitrone) and that they will monitor eye pressure more and have a second eye drop they can add if needed. He said treat the cancer first.

[akaipop3ps in reply to lgutman]

Thanks, good to know.