hypertension due to Lupron and Zytega - Advanced Prostate...

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hypertension due to Lupron and Zytega

fredyworks profile image
12 Replies

I was diagnosed in 2018 psa 87 Gleason 9

3 Mets low burden invasion to Vesicles

Imrt radiation that caused calcification damage to bladder neck that has been resolved by hbot . I’m still have frequent urination at nigh due to thickening of bladder wall.

I use top doctor vascular surgeon at penn

With many years of experience and is head

Of entire unit .

My blood pressure was good four 4.5 years now it is hard to control.

I am on HYDRALAZINE .

What other natural ways can I possibly use

to help other the the proper diet and exercise program that I am using

I am business owner and continue to operate two companies at one time

even though I have sleep deprivation.

I will be on Medicare in October and I

Will find better treatment by other doctors

In other part of USA.

My wife has Doctors in the family different part of medicine.

And also I have background in different science other then medicine.

I don’t trust Doctors I have bought them

In giving misinformation !

I follow the science !

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fredyworks
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12 Replies
tango65 profile image
tango65

When you take zytiga, the suprarenal glands stop producing all the hormones., except for aldosterone. Aldosterone is a hormone which reabsorbs sodium and eliminates potassium in the kidneys.

Since cortisol is not being produced by the suprarenal glands there is an increase of ACTH, the hormone that stimulates the suprarenal. This eventually leads to an overproduction of aldosterone with sodium retention, potassium loss (hypokalemia) and water retention with edema and hypertension.

To avoid this situation zytiga is given with prednisone which stops the increase in ACTH and eventually aldosterone.

If you are having hypertension with zytiga, you could discuss increasing the dose of prednisone and see what happens and if the BP continues to be elevated they could use eplerenone which is a specific receptor blocker for aldosterone.

There are data showing that with a dose enough of eplerenone it is possible to give zytiga and control the BP even when prednisone is not used.

jmarsh profile image
jmarsh in reply to tango65

I didn't like the higher 10mg dose of Pred due to side effects - thin skin, bruising, etc. I take Losartan for BP (I didn't have hypertension prior to ADT) and just increased the dose to cover for the Pred. Might not work for everyone but works for me. Hoping to go off Lupron and Abi/Pred in June. It will interesting to see if BP returns to normal eventually.

tango65 profile image
tango65 in reply to jmarsh

It is other approach that may work for some.

Grandpa4 profile image
Grandpa4 in reply to jmarsh

Same situation for me and same treatment. I was able to come down to 50 mg of losartan after stopping abiraterone 1 month ago but not yet off. Did not have hypertension before either.

j-o-h-n profile image
j-o-h-n in reply to tango65

I hope you dance as well as your post (you're a blessing)...

Good Luck, Good Health and Good Humor.

j-o-h-n

robobob7777 profile image
robobob7777 in reply to tango65

Well in my case, I have Conns or primary aldosteronism. And my pressure on all kinds of HBP meds kept my pressure to around 175/115 for 30 years.I do not take prednisone. I already take plenty or mineralocorticoid which acts similar to glucocorticoids, I produce super amounts of aldosterone, now with these meds I'm sitting around 133/93.

tango65 profile image
tango65 in reply to robobob7777

What mineralocorticosteroids do you take?

garyjp9 profile image
garyjp9 in reply to tango65

Hi, are you familiar with any such data?

tango65 profile image
tango65 in reply to garyjp9

ncbi.nlm.nih.gov/pmc/articl...

garyjp9 profile image
garyjp9 in reply to tango65

Thank you very much

robobob7777 profile image
robobob7777

Well, as you said best way is diet and exercise. To me, sounds like you have anxiety causing sleep deprivation, so add Clonidine to your meds.

Hydra is not the best for HBP. They recommend Calcium channel blockers, but careful, long term use may cause cancer or worse cancer.

There other good options Beta blockers, alpha blocker and Diuretics. And still to other popular type of treatments.

I'm guessing, they will add diuretics. Hydralazine you are taking kinda sucks. You have to take it more than once a day, probably 3. Right there, you have to almost wake up between pills.

I'm just a Hick, who reads and reads. But I have been on everything on the planet with HBP for 40 years. Nothing worked, I was hypertensive resistant on 3 max dose pills.

Turns out, I have a rare, although they are finding it is not that rare but was difficult to diagnose, primary Hyperaldosteronism , Which means, over active adrenal glands.

Professorgary profile image
Professorgary

Curcumin with black pepper extract and magnesium.

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