BAT and Xtandi

[gsun]

I'm not quite understanding the timing of dosing of Xtandi during BAT. Dr Denmeade wrote this article ( and i think it's great) but I'm not getting when you take Xtandi during BAT. The BAT cycle is 28 days. Do you take Xtandi during the cycle or is it when BAT starts to fail, then take it and start BAT again?

[Tall_Allen]

In his current trials with BAT and Xtandi, patients (who are asymptomatic mCRPC and who have failed Zytiga) stay on ADT throughout. In addition, they are randomly assigned to one of 3 groups:

A. Xtandi

B. Two months of high T followed by two months of Xtandi. Repeat.

C. Up to four months of high T, if progression, followed by Xtandi. If progression, T is repeated.

clinicaltrials.gov/study/NC...

Patients are very closely monitored with PSA and scans.

[gsun in reply to Tall_Allen]

Thanks for clearing that up. Hope some results come soon.

[Tall_Allen in reply to gsun]

July 2025

[Ramp7 in reply to Tall_Allen]

Nubeqa may also be considered, it washes out of the body more quickly and does not cross the brain barrier.

[Tall_Allen in reply to Ramp7]

Nubeqa is not allowed on that clinical trial, only Xtandi. Very few men, those that suffer from epilepsy, are concerned with drugs that cross the BBB.

[EdBar]

Sartor discontinues Xtandi during BAT which makes sense since you don’t want to block the tastosterone from reaching cancer cells. He has you remain on Lupron so the testosterone levels fall quickly hence the cycling or bipolar. Eventually BATis no longer effective and you give Xtandi another try, often it reactivates Xtandi thus extending its usefulness.

Ed

[gsun in reply to EdBar]

The third group in the study is to use testosterone until it fails and go on Xtandi. When it fails go back to testosterone. By “fails” I mean a PSA rise to a certain level

[Hidden in reply to gsun]

This is what I am doing, works very well

[gsun in reply to Hidden]

How long have you been doing it?

[Hidden in reply to gsun]

A year