AMG 509

[Magnus1964]

Link to an article on AMG 509

links.mkt1881.com/els/v2/~d...

[Ramp7]

Be curious if any Stage III trials are planned.

[Maxone73 in reply to Ramp7]

You are less patient than I am!

[Maxone73 in reply to Ramp7]

classic.clinicaltrials.gov/...

Phase 1 is still recruiting

[mypk in reply to Maxone73]

I'm in that AMG-509 trial. According to what I was told recently, Amgen is now stopping recruiting more patients because they reached the planned number of participants.

[Maxone73 in reply to mypk]

Ok! How is it going?

[mypk in reply to Maxone73]

In my case it generates a lot of hard to bear side effects like continuous fatigue, bone pain, cough irritation, a stiff and hurting neck, heavy sweating during the night, often a headache. My PSA is fluctuating between 150 and 240, so that's not a reliable marker. But CT and bone scans show a stable disease, so my bone metastases neither get worse or shrink.

[Maxone73 in reply to mypk]

Damn, tough therapy

[Magnus1964 in reply to mypk]

Thank you for sharing that. Do you know if other on the trial experience the same side effects?

[mypk in reply to Magnus1964]

I have no contact with anyone else in the study, so I don't know whether others have the same experience as me.

There is some information about treatment-related adverse events on this page:

urotoday.com/conference-hig...

[mypk]

"Damn, tough therapy"

Phase 1. 😀 Hopefully Amgen can reduce the ugly side effects in the future.

[Maxone73]

ok phase 1 but, if I can ask, we’re your Mets progressing before the trial?

[mypk in reply to Maxone73]

No, my metastases have been kept stable since 2020 with Trenantone/ XGEVA plus in sequence: Docetaxel > Ra-223 > Abiraterone > Cabazitaxel and now AMG-509

[Maxone73 in reply to mypk]

I am on denosumab as well...

[GSDF]

Good article, thanks Mag...

[Big_Mcc]

Thku. Very interesting read

[Spyder54]

Thanks Magnus,

I read MyPK’s comments above. Not super encouraging.

But….there is another guy on this site that was a very early recruit who raved about his excellent results. Many asked about his experience and most had not heard of AMG509. Hopefully he will see this and jump in. If I knew his name I would say, but do not remember. My thought at the time was Lucky Dude.

Mike

[mypk in reply to Spyder54]

"I read MyPK’s comments above. Not super encouraging. "

Amgen certainly needs to work on the toxicities before they go into Phase 2 trials at some point. And as a patient I would not look primarily at the PSA value. What really counts is an improvement in the imaging.

[MoonRocket in reply to Spyder54]

The moniker was unknown58 and he was most likely a fraud.

healthunlocked.com/advanced...

[Tyson53 in reply to Spyder54]

It’s been a while since I’ve chatted here. After seeing the posts, I thought I would share my AMG509 treatment history. Started Jan 2022 at dose of 0.1. PSA rapidly declined to undetectable. Treatment was weekly infusion. Side effects included several rashes and a few aches but nothing that wasn’t cleared up quickly with some triamcinone acetonide cream. After about a year on the trial I developed pain in my head and jaw. It worsened over time. Dr figured out that I suffered from arterial vasculitis. By this time the pain was severe. Steroid treatment got rid of it but there was suspicion that the AMG contributed to this. I was removed from the trial in March 2023. As of Nov 2023 scans and bloodwork, my PSA is still undetectable and Mets are stable. However Nov scans showed enlarged mesenteric lymph nodes. More tests soon.

[mypk in reply to Tyson53]

Thank you for sharing your AMG-509 experience. May I ask if you had a lot of bone metastases at the time you entered the trial? When my AMG-509 treatment started, I had stopped counting my mets at 75. I'm treated with a dose of .75 and that leads to several treatment-related adverse events.

[Tyson53 in reply to mypk]

I was never given quantities of Mets. Usually only locations. Interpreting a bone scan is way over my head. It seems to me that a “black” spot that shows up on a bone scan is not confirmation of cancer. I had one large “black” spot on my femur biopsied twice. No cancer cells were found.

[mypk in reply to Tyson53]

Thank you for your reply. Sounds like your case is very different from mine, so not comparable.

[mypk in reply to mypk]

One day after the 30th infusion, severe, almost unbearable pain developed in both shoulders. During the night, I could have screamed out loud with every movement. Pain-relieving tablets hardly brought any relief.

In addition, AMG-509 sometimes causes jaw tightness, which makes eating difficult.