A New Map Reveals the Complicated World in Which Cells Seek to Repair Damaged DNA
Damage to DNA and replication errors caused by stress and other factors play a major role in disease, and are a hallmark of cancer and other afflictions. To maintain the integrity of the genome and support normal functioning and health, cells have evolved an intricate network of cell-cycle checkpoints and DNA damage repair tools, collectively known as DNA damage response or DDR.
Defects in DDR are linked to numerous diseases, including cancer and heritable neurological disorders caused by unstable DNA, erroneous repeats, rearrangements and mutations. Conversely, better understanding how DDR works and why it sometimes fails provides new therapeutic opportunities to treat or cure the same diseases.
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Simvastatin & Radioresistance.
