Prazosin

[Scout4answers]

from India

[Scout4answers]

box

[Kaliber in reply to Scout4answers]

first one is free … yayahahahaya

❤️❤️❤️

[Spyder54]

Scout, what is the story on Prazosin?

I dont know anyone else using it.

Thanks, Mike

[Scout4answers in reply to Spyder54]

I was taking Tamsulosin for BPH and asked my Urologist to switch me to Prazosin and he agreed when I showed him a study that it MAY be helpful against PCa. I look at it as a low risk potentially high reward move. I am taking Pitavastatin for the same reason.

Both of these drugs have small studies that indicate they may slow progression of PCa

pubmed.ncbi.nlm.nih.gov/149...

Apoptotic impact of alpha1-blockers on prostate cancer growth: a myth or an inviting reality?

Anastasios Tahmatzopoulos 1, Natasha Kyprianou

Affiliations expand

PMID: 14991869 DOI: 10.1002/pros.10357

Abstract

Background: Pharmacological manipulation or genetic targeting of the major apoptosis regulators, such as bcl-2, caspases, and inhibitors of apoptosis (IAPs), represent clinically attractive avenues towards effective therapeutic strategies for advanced prostate cancer. A wealth of evidence established the alpha(1)-adrenoceptor antagonists to be clinically effective in relieving the symptoms associated with benign prostatic hyperplasia (BPH) by relaxing prostatic smooth muscle tone. This action alone however does not fully account for the long-term clinical response to these drugs in BPH patients.

Methods: Experimental and retrospective clinical studies provided new evidence supporting a differential growth-suppressing function of two alpha(1)-adrenoceptor antagonists against prostate cancer, independent of an alpha(1)-adrenoceptor mechanism.

Results: The quinazoline-based antagonists, doxazosin and terazosin, induce apoptosis, inhibit cell adhesion to the extracellular matrix (by activating anoikis), and prevent cell invasion and migration of prostate tumor epithelial cells and vascular endothelial cells. Tamsulosin, a sulphonamide-based, clinically effective alpha(1)-adrenoceptor antagonist for BPH treatment, fails to exert a similar apoptotic action against prostate cells. Furthermore, at pharmacologically relevant doses, doxazosin suppresses benign and malignant prostate growth in in vivo experimental models. The effect is characterized by three intriguing features: (a) it is mediated by an alpha(1)-adrenoceptor-independent action, (possibly related to the quinazoline nucleus); (b) it is targeted at the apoptotic process without affecting cell proliferation; and (c) the elevated apoptotic index correlated with symptom score improvement in BPH patients.

Conclusions: This evidence challenges conventional knowledge of the mechanism of action of alpha(1)-adrenoceptor antagonists, and points to a new therapeutic value for these drugs by providing a differential molecular basis for their anti-tumor efficacy. The present review focuses on the characterization of the apoptotic/anti-angiogenic effect of quinazoline-based alpha(1)-adrenoceptor antagonists against prostate cancer cells and discusses the clinical significance of this action in the prevention and treatment of prostate cancer.

[Spyder54 in reply to Scout4answers]

thanks for the positive response Scout. Mike

[Purple-Bike in reply to Spyder54]

The diagram is from a retrospective study with the limitations this has, but the diagram indicates a vast superiority of prazosin vs tamsulosin for PCa. Both were used to treat Lower Urinary Tract Syndrome for the patients in question and both are α1-adrenoceptor antagonists, but prazosin is a quinazoline α1 antagonist and tamsulosin a sulphonamide derivative.

Preclinical studies are of limited use on their own, but strengthen what clinical data there is.: “There is substantial evidence that the quinazoline (terazosin, prazosin and doxazosin) display cytotoxicity in prostate cancer cell lines, effects that are not observed with the sulphonamide derivative tamsulosin. ........ In vivo studies in mice have shown that these effects also occur at clinically relevant doses, with reduction in tumour growth, metastasis and decreased angiogenesis observed in models of prostate cancer”

So lab and animal studies show protective effects from prazosin but not from tamsulosin. The retrospective study on men likewise showed a greatly superior effect of P compared to T and controls. It is of course very very far from certain, but I think a case can be made that the odds are not very bad that prazosin just might be a game changer. As Scout4answers says, a low risk potentially high reward move.

Prazosin is used to treat high blood pressure as well, so one has to check that systolic or diastolic pressure does not get too low.

Recurrence free survival PCa. Blue is control group.

[Hidden]

you are way out on a limb. Be sure and involve Cardiologist and Medical Oncologist……. pubmed.ncbi.nlm.nih.gov/296...

GD

[Scout4answers in reply to Hidden]

see my reply to Spyder above

[lcfcpolo]

Good luck but definitely discuss with your Oncologist.

Which pharmacy in India supplied this please?

Graham

[Scout4answers in reply to lcfcpolo]

see my reply to Spyder above

AllDay Chemist

[Hidden in reply to Scout4answers]

And your Cardiologist says, what?

[MateoBeach]

I’m with you on this Scout. Except I chose to go with Doxazosin over Prazosin due to the in vivo results, possibly related to longer sustained blood levels due to half life. I take 2mg twice daily as part of my BP control regimen. Had to watch orthostatic hypotension and go slow initially but after a few weeks no problem.

The effects in slowing growth and decreasing metastasis in PC appears real and significant from the available evidence. So not sure why this is not more widely deployed.

Those are both generic and available on Medicare Part D inexpensively, so not sure why sourcing from India. Paul

[Scout4answers in reply to MateoBeach]

I have been experiencing orthostatic hypotension on nights when I take Cialis. Have been cutting out nightly Prazosin and or Lisinopril to manage BP. Not willing to give up Cialis

[MateoBeach in reply to Scout4answers]

I understand completely. I take sildenafil 40 mg most days, most often in late mornings. Shorter duration so may be less around by nighttime. Cialis can last 2+ days!

Prazosin has 30-90 min to peak and 2-3 hr half life, so it has more peaks & troughs so that may be part of the problem. Considering doxazosin appears equally beneficial for PC (effects believed unrelated to the alpha1 blockade for BP effects. It has a 10-12 hour terminal half-life, and there is also an extended release form which has even greater smoothing of levels and hence lower orthostatic hypertension risks.

I’d rather sort that out than try to get by with just one morning dose of short acting prazosin. Nighttime BP control is important to according to Peter Attia. Paul

[irakor]

Prazosin has a common side effect: fast, irregular, pounding, or racing heartbeat or pulse. Statins also have a lot of side effects, my husband (83 yo) uses Endur-Acin instead . I believe you don't have any heart problems. Do you use other repurposed anti-cancer drugs? Thanks

[gsun]

I tried Prazosin. I was taking Tamsolusin for urinary problems - which it works great for- but after reading about Prazosin, I switched. It knocked me on my ass. My BP went so far down I couldn't do anything. Stopped after just a couple days. If you are taknig BP meds, this could be good for you.