Trials for alternatives to Pluvicto?

[tallguy2]

Are any of you participating in a phase 1 or phase 2 trial studying an alternative to the radioligand Pluvicto?

I ask because I was one business day away from getting my first dose of Pluvicto when new patients were turned away due to quality control problems. Based on part of the Novartis news release late last week (shown below) new patients like me may be hosed for the rest of 2023.

Thanks.

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In the letter, the company said that it currently only manufactures Pluvicto in Italy in "small batches," and is awaiting FDA approval on a new manufacturing site. That approval was expected to come in four to six months, Novartis said. Novartis said it will not take any new orders until there is "clarity on the FDA's approval" of its new manufacturing facility. 

[tango65]

list of all trials of Lu 177

clinicaltrials.gov/ct2/resu...

This is the most similar to Pluvicto (I had this ligand in Germany in 2016, very effective)

clinicaltrials.gov/ct2/show...

[tallguy2 in reply to tango65]

Thank you. I am also looking for alternatives to Pluvicto.

[tango65 in reply to tallguy2]

Best of luck!!

[Tall_Allen]

There are several clinical trials in the US of Pluvicto alternatives (anything other than Lu177PSMA-617):

prostatecancer.news/2020/08...

The Cu-67-SAR-bisPSMA is promising.

Otherwise, you can go to Germany to get different ligands - I think Lu177PSMA-I&T is inwidespread use there.

[tallguy2 in reply to Tall_Allen]

Thank you.

[Brbnbrn]

Oh no! We're waiting too! He's on nothing but Lupron right now. We meet with Dr. V at the University of Michigan on April 3rd. I'll let you know what she says.

[tallguy2 in reply to Brbnbrn]

Thanks, and best wishes!

[j-o-h-n]

Sono pazzi nella testa...

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 03/22/2023 8:13 PM DST

[Brbnbrn in reply to j-o-h-n]

Who's that John? The doc's a bit crazy?

[j-o-h-n in reply to Brbnbrn]

The whole world.....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 03/23/2023 3:41 PM DST

[Brbnbrn in reply to j-o-h-n]

I know. Gotta' look for those rainbows.

[j-o-h-n in reply to Brbnbrn]

Well put.................thanks

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 03/24/2023 11:38 AM DST