PSA increase after first Pluvicto infusion

[JoeyDad]

mine went to 57 from 27 but pain is down. Also, hadn’t had lupron shot in 5 months. Has this happened with anyone else?

Joey Dad

[tango65]

If your testosterone is above castration levels it could explain the increase in PSA.

How many weeks did you wait before measuring the PSA after the Pluvicto treatment?

[john4803 in reply to tango65]

I am getting my first injection next week, as part of the Eclipse Trial, and they said it was not uncommon for an increase after the first. I think it has to do with the dying cancer. It may even be a sign that the therapy is working? You might ask them?

Of course, the scans will tell what is going on.

[JoeyDad in reply to john4803]

Wow!! Thanks for responding!

[john4803 in reply to JoeyDad]

Did he have any problem with his saliva glands. As part of the consent form for this trial, they said they would apply ice to them before and after the injection but now they are saying they have found it is not a problem. What dosage did he get?

[JoeyDad in reply to tango65]

5 weeks

[tango65 in reply to JoeyDad]

It is adequate interval to measure the PSA.Did they measure your testosterone?

[JoeyDad in reply to tango65]

yes - went up. Got lupron injection.

[Yank66]

Hang in there. We were told PSA could increase after treatment. I have to admit we’d be discouraged if that had happened, but realize it still could. The roller coaster continues. Best wishes to you.

[j-o-h-n]

Roller coaster and dirt country road.

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 03/03/2023 3:18 PM EST

[Ollie1948]

It happened to me... I got the second shot but didn't check the PSA yet.

[JoeyDad in reply to Ollie1948]

my PSA went up after first infusion o Pluvicto…after 2nd infusion my PSA dropped to 19 from 53. Onward!!

[barrybayarea]

I have had 3 shots so far, the PSA is still not down to where it used to be when I started, at the end of chemo. Still not sure if it is the dying cells or new cancer growth -

09/12/2022 - 7th round of chemo. PSA down to 9.04 from 17

10/20/2022 - PSA 12.44 - Pluvicto started

11/08/2022 - PSA 16.47

11/29/2022 - PSA 13.892, 2nd Pluvicto infusion

01/11/2023 - PSA 23.115, 3rd Pluvicto infusion

02/01/2023 - PSA 19.15

02/01/2023 - PSA 21.37, 4th Pluvicto infusion delayed due to the shortage.

[Kian28]

My PSA jumped up after first infusion of Pluvicto.......from 32.5 to 42.6. Oncologist said all is normal for PSA to do this. Will get some fluids pumped into me next Monday in hopes i will come out of this feeling of down and sore and no energy.