Natural Phytochemicals that Modulate Innate Immunity Pathways That Promote Inflammation

[MateoBeach]

Inflammation is one of the two main underlying drivers of "The Hallmarks of Cancer", the factors affecting cancer development and progression. The other being progressive genetic instability (DNA mutations).

Our innate immune response pathways trigger cascades of cellular mechanisms that include promoting inflammation, that often persist even after a threat of infection. These are harmful. The very comprehensive article linked below describes these mechanisms and pathways in detail. Especially the TLR4 and Nf-kB antigen response pathways and how these release inflammation. And furthermore, how epigenetic signaling control mechanisms modulate the inflammatory responses. (Through Histone modifications, DNA Hyper-methylation and mi-RNAs.)

It may be too much cellular biochemistry for many, but it includes a review of several important natural plant-derived phytochemicals that affect all of these mechanisms in potentially beneficial ways. This is a good review of their scientific basis for those who might want to include more of these food sources, or even supplement them. I am not recommending any supplements for treating prostate cancer, even though I do use several of them myself. Only Sulforaphane has a proven benefit in clinical trial.

The specific phytochemicals discussed include "the usual suspects": Resveratrol, Curcumin, Quercetin, Sulforaphane, EGCG, Genistein, Apigenin, Emodin, Anthocyanins, Ellagic Acid, Terpenoids, Carracol/Thymin, Boswellic Acid, AITC-Sinigrin, and Cinnamaldehyde.

The Anti-Inflammatory Properties of Phytochemicals and Their Effects on Epigenetic Mechanisms Involved in TLR4/NF-κB-Mediated Inflammation

ncbi.nlm.nih.gov/pmc/articl...

Note that there is a more detailed discussion on "The Hallmarks of Cancer" in one of my previous posts by that title. MB / Paul

[cesces]

Is there a specific action this would recommend that we take?

[Rickmartin1948]

Great pile of info 😀👍