Natural Phytochemicals that Modulate ... - Advanced Prostate...

Advanced Prostate Cancer

22,869 members28,485 posts

Natural Phytochemicals that Modulate Innate Immunity Pathways That Promote Inflammation

MateoBeach profile image
2 Replies

Inflammation is one of the two main underlying drivers of "The Hallmarks of Cancer", the factors affecting cancer development and progression. The other being progressive genetic instability (DNA mutations).

Our innate immune response pathways trigger cascades of cellular mechanisms that include promoting inflammation, that often persist even after a threat of infection. These are harmful. The very comprehensive article linked below describes these mechanisms and pathways in detail. Especially the TLR4 and Nf-kB antigen response pathways and how these release inflammation. And furthermore, how epigenetic signaling control mechanisms modulate the inflammatory responses. (Through Histone modifications, DNA Hyper-methylation and mi-RNAs.)

It may be too much cellular biochemistry for many, but it includes a review of several important natural plant-derived phytochemicals that affect all of these mechanisms in potentially beneficial ways. This is a good review of their scientific basis for those who might want to include more of these food sources, or even supplement them. I am not recommending any supplements for treating prostate cancer, even though I do use several of them myself. Only Sulforaphane has a proven benefit in clinical trial.

The specific phytochemicals discussed include "the usual suspects": Resveratrol, Curcumin, Quercetin, Sulforaphane, EGCG, Genistein, Apigenin, Emodin, Anthocyanins, Ellagic Acid, Terpenoids, Carracol/Thymin, Boswellic Acid, AITC-Sinigrin, and Cinnamaldehyde.

The Anti-Inflammatory Properties of Phytochemicals and Their Effects on Epigenetic Mechanisms Involved in TLR4/NF-κB-Mediated Inflammation

ncbi.nlm.nih.gov/pmc/articl...

Note that there is a more detailed discussion on "The Hallmarks of Cancer" in one of my previous posts by that title. MB / Paul

Written by
MateoBeach profile image
MateoBeach
To view profiles and participate in discussions please or .
Read more about...
2 Replies
cesces profile image
cesces

Is there a specific action this would recommend that we take?

Rickmartin1948 profile image
Rickmartin1948

Great pile of info 😀👍

Not what you're looking for?

You may also like...

The Hallmarks of Cancer: Preserving Health and Longevity while fighting Prostate Cancer

Note: I have been thinking about these ideas over some weeks and how they might apply to...
MateoBeach profile image

Resveratrol Revisited. For Gut Microbiome.

  There are several domains, or perhaps I should say tiers, of interest in the overall...
MateoBeach profile image

"DNA methylation in development and disease: an overview for prostate researchers"

New paper [1] that discusses PCa hypermethylation & (reversible) epigenetic changes. I have been...
pjoshea13 profile image

Colchicine and Inflammation Revisited

Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common...

Anticancer Effects of Nutraceuticals in the Mediterranean Diet: An Epigenetic Diet Model

New Italian paper below [1]. Two of my favorite topics: nutraceuticals (mostly polyphenols found...
pjoshea13 profile image

Moderation team

Bethishere profile image
BethishereAdministrator
Number6 profile image
Number6Administrator
Darryl profile image
DarrylPartner

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.