Been looking for list or chart or something comparing enzalutemide, darolutamide & apalutemide with no success. So, I came up with my own. I am sure this is not complete. Please feel free to suggest edits. Thanks.
Apalutamide - take w/ or w/out food; once daily
- half life 3 days
- moderate CNS penetration
Enzalutemide - w/ or w/out food; once daily
- longest half life (6 - 8 days)
- highest % of fatigue, falls, seizures (greatest CNS penetration), constipation
- potential increase potency of statins
Darolutamide - w/food; twice daily
- 20 hr. half life
- highest binding affinity to androgen receptors
- lower CNS penetration (potentially less brain fog?)
- less drug interactions
- lower % of fatigue, falls, rash, seizure
- potential increase potency of statins, esp. Crestor