Trials after lu-psma treatment ends?

[ellie2211]

Hi everyone.

 My father is at the end of his 6 doses of pluvicto . We will be asking his oncologist about getting into a t-cell clinical trial. And have him get another liquid biopsy.

What other trials should we be looking at? Any advice is welcome.

[GP24]

I would observe and get another PSMA PET/CT to see the results of the therapy. Instead of a clinical trial your father could get Provenge. This is an FDA approved immunotherapy.

[ellie2211 in reply to GP24]

We asked about provenge but his old Onc said that he was too advanced for it and that it is only really useful in earlier stages. We haven't asked his new one yet.

[GP24 in reply to ellie2211]

Usually Provenge is used at a bit early stage. However, I would rather use a drug that I know will work than try something which nobody knows how well it works.

[tango65]

You could start by looking at the PC clinical trials at the Institution your doctor works and then what is offered for PC trials at UCSF, UCLA, City of Hope, Dana Farber, MSKCC in NY, MD Anderson, Tulane, Duke etc. , made a list of these clinical trials and consult with your doctor if any of those could be indicated for your father.

You could also search for preliminary data for each one of the trials. Most of them will be phase I or II and nothing has been presented or published. It is a lot of work, but in my experience, the doctors do not offer any clinical trial if they or the institution where they work is not participating in the trial.

[ellie2211 in reply to tango65]

Thanks, that has been our approach. He is at UCLA but we want to get a consultation with city of hope for the car t trial.

I'm curious what trials others are considering.

[tango65 in reply to ellie2211]

It will depend on their clinical situation.

If your father has a good response to Lu 177 PSMA treatment they could try the new anti androgens and see if the cancer responds. CAR T cells therapies do not work very well in solid tumors and they have significant risks. UCSF and Stanford have many clinical trials.

[ellie2211 in reply to tango65]

Of course. Everyone is in a unique situation. Always good to have as much info as possible

[NWLiving]

So he received 6 rounds of Lu 177? Did it work at all for him?

[ellie2211 in reply to NWLiving]

It has been working for him. Has kept his PSA pretty stable.

[Ramp7]

Just received my 5th LuPSMA177 infusion this week. PSA is 0.23. I asked the MO at Dana Farber if and when the PSA goes up would employing BAT be practical. She said yes but only within a trial study. She would administer it as SOC. Food for thought.

[Ramp7 in reply to Ramp7]

Would NOT administer it as SOC.

[HopingForTheBest1]

How did he do on LU177?

[ellie2211 in reply to HopingForTheBest1]

PSA has stayed low but the delay in production maybe caused a bit of an uptick on his last blood work

[HopingForTheBest1 in reply to ellie2211]

Good to hear about PSA. Any effect on his salivary glands; dry mouth?

[ellie2211 in reply to HopingForTheBest1]

I think a bit of dry mouth and fatigue, but he doesn't complain about it much. Otherwise he has felt pretty good.

[Janhpr]

My husband has widespread bone mets had his 3rd dose of Lu 3 weeks ago (privately) PSA down from 10.4 in March to 5,8 now, he is very fatigued, poor mobility and backache, keeping cheerful just wondering like you what next, don’t want chemo again, hospitalised 3 times because was neutopenic, followed by multi pulmonary embolisms, also since RT has bowel problems. Interested options that you are considering

[NWLiving in reply to Janhpr]

Did he feel better a few weeks after the treatments? It’s been about 3 weeks after Bills treatment and he seems to be better overall, and his mind clearer. He did just randomly toss his cookies this morning.