Dostarlimab

[Fight11]

In regards to the clinical trial with this drug and colorectal cancer was so amazing . May this be used for prostate cancer as well? Is this similar to Keytruda?

[tango65]

Yes it could be used if the cancer has mutations such as MSI-H or d MMR.

merck.com/docs/Understandin...

These mutations are infrequent in PC.

[Fight11 in reply to tango65]

How about CDK12

[tango65 in reply to Fight11]

It may offer some control of the cancer in a minority of these patients.

pubmed.ncbi.nlm.nih.gov/326...

[Fight11 in reply to tango65]

Is it similar to Keytruda?

[KocoPr in reply to tango65]

I have msh6-loss I will ask about keytruda. I don’t see where dostarlimab is approved yet. Do you see it approved?

[tango65 in reply to KocoPr]

It is approved for dMMR in solid tumors. The commercial name is Jemperli

accessdata.fda.gov/drugsatf...

[Fight11 in reply to tango65]

Tango please forgive me. My husband has the CDK 12 mutation would that fall in that category

[tango65 in reply to Fight11]

No.

It seems the genes involved in MMR are :

"" MMR machinery in humans has 8 genes that code for its components: hMSH2, hMSH3, hMSH5, and hMSH6, while MutL homologs are hMLH1, hPMS1 (hMLH2), hMLH3, hPMS2 (hMLH4) (Lipkin et al., 2000; Clark et al., 2013; Amaral-Silva et al., 2017).""

CDK12 gene is related to:

""CDK12 regulates the transcription of long DNA repair genes (such as BRCA1,BRCA2,ATR,ATM,Fanconi anaemia), predominantly those involved in the HR repair pathway ""

""Homologous recombination (HR) is a molecular pathway involved in a multitude of processes, from the generation of genetic diversity to DNA repair and replication. HR provides a mechanism for the accurate repair of DNA double-strand breaks, protecting cells from chromosomal aberrations such as those seen in cancer.""

[tango65]

yes, both bind to the PD-1 receptor in the T cells.

[Fight11 in reply to tango65]

My husband failed Keytruda! I wonder is he will be eligible for this one! Doesn’t hurt to try

[Aodh]

I read (in a U.K. newspaper) that MSK are planning a trial of Dostarlimab to include prostate cancer patients among others cancer types. However the paper provided no further details. I expect that there’s more information in the U.S.

Newspapers tend to be very upbeat about potential new cancer treatments, there’s no harm in asking MSK, but please manage your expectations; the reported colorectal study result had a small number of participants. Also there was no mention of the outcomes for endometrial cancer patients for whom the drug was initially targeted.

Like most cancer patients, I too want this to be a wonder drug capable of curing all solid tumor cancers at any stage of progression, but I caution it’s very early and too soon to invest my precious hope only to have it dashed.

I wish you and your husband the very best.

Hugh

[j-o-h-n]

Let us hope....it turns those ugly little monsters into body fat eaters (when we eat ice cream)...

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 06/08/2022 6:38 PM DST