A 6 minute watch. I can back up most of what he says with multiple trials and studies and research.

Does Sugar Feed Prostate Cancer? Does Fatty/Adipose Tissue Attract Cancer? | Mark Moyad, MD, MPH - YouTube

youtube.com/watch?v=-Pyqazl...(Not working as expected?)

[fmenninger]

great video.....we all goota stay lean and mean! Ha ha...

Stay strong

[Hidden in reply to fmenninger]

Yup. The exercise/obesity data is one area that I can easily get behind. The master bedroom is now 100% gym. I simply told my wife that I had to make a home gym for therapeutic reasons. Lol! She knows... But, kudos to my wonderful wife, she let me do it and has never complained.

1. Association of Muscle Mass with Survival after Radical Prostatectomy in Patients with Prostate Cancer

pubmed.ncbi.nlm.nih.gov/309...

2. Exercise-induced biochemical changes and their potential influence on cancer: a scientific review: Robert James Thomas, Stacey A Kenfield, Alfonso Jimenez

bjsm.bmj.com/content/bjspor...

3. A prospective study of physical activity and incident and fatal prostate cancer: Edward L Giovannucci, Yan Liu, Michael F Leitzman, Meir J Stamfer, Walter C Willett

pubmed.ncbi.nlm.nih.gov/158...

4. Recreational Physical Activity in Relation to Prostate Cancer-specific Mortality Among Men with Nonmetastatic Prostate Cancer: Ying Wang, Eric J Jacobs, Susan M Gapstur, Maret L Maliniak, Ted Gansler, Marjorie L McCullough, Victoria L Stevens , Alpa V Patel

pubmed.ncbi.nlm.nih.gov/287...

5. MET-hour equivalents of various physical activities

health.harvard.edu/staying-...

6. Muscle Mass Index as a Predictor of Longevity in Older-Adults Preethi Srikanthan, M.D., M.S. and Arun S. Karlamangla, M.D., Ph.D

ncbi.nlm.nih.gov/pmc/articl...

7. Why Exercise Is Important When You Have Prostate Cancer, and the Best Workouts to Do: Maria C Masters

livestrong.com/article/1372...

8. Muscle–Organ Crosstalk: The Emerging Roles of Myokines: Mai Charlotte Krogh Severinsen, Bente Klarlund Pedersen

academic.oup.com/edrv/artic...

9. Exercise in cancer - PMC

ncbi.nlm.nih.gov/pmc/articl...

10. Exercise-induced biochemical changes and their potential influence on cancer: a scientific review: Robert James Thomas, Stacey A Kenfield, Alfonso Jimenez

bjsm.bmj.com/content/51/8/640

11. American Cancer Society guideline for diet and physical activity for cancer prevention - Rock - 2020 - CA: A Cancer Journal for Clinicians - Wiley Online Library

acsjournals.onlinelibrary.w...

12. Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells – PubMed (Myostatin inhibition leads to non-androgenic muscle hypertrophy)

pubmed.ncbi.nlm.nih.gov/230...

13. Greater stimulation of myofibrillar protein synthesis with ingestion of whey protein isolate v. micellar casein at rest and after resistance exercise in elderly men – PubMed

pubmed.ncbi.nlm.nih.gov/222...

14. Myokine Signaling Blockade Prevents Androgen Deprivation Therapy Induced Sarcopenia and Suppresses Tumor Growth: Chunliu Pan Shalini Singh John Krolewski Kent Nastiuk

faseb.onlinelibrary.wiley.c...

15. The effects of different exercise training mode on interleukin, 15_life0403_82_86.pdf

lifesciencesite.com/lsj/lif...

[Heilung18-Gesund in reply to Hidden]

Thanks for a comprehensive, great list of refs!

Another ref re training effect on PCa-associated myocardial atrophy:

Am J Transl Res. 2021 Jan 15;13(1):197-209. Effects of high-intensity training on prostate cancer-induced cardiac atrophy

(Sorry - in vitro and rats)

PCa independent of treatment has atrophic effects on whole heart and left ventricular (LV) masses, associated with reduced endurance exercise capacity.

Dunning R-3327 AT-1 prostate cancer cells (1×105) were injected into the ventral prostate lobe of 5-6 mo immunocompetent Copenhagen rats (n=24).

two groups, tumor-bearing exercise (TBEX, n=15) or tumor bearing sedentary (TBS, n=9).

no significant differences in tumor mass between groups (TBEX 3.4±0.7, TBS 2.8±0.6 g, P=0.3), or body mass (TBEX 317±5, TBS 333±7 g, P=0.2).

Heart-to-body mass ratio was lower in TBS group compared to TBEX (2.3±0.1 vs. 2.5±0.1 mg/g, P<0.05).

LV/body mass ratio was also lower in the TBS group (1.6±0.1 vs. 1.8±0.1 mg/g, P<0.05).

From Pre-Post, TBEX had significant increases in SV (~20% P<0.05) whereas TBS had no significant change.

no significant differences between groups for markers of protein degradation.

high-intensity exercise can improve LV function and increase LV mass concurrent with prostate cancer development, versus sedentary counterparts.

Also, beneficial effects of training on tumor-immune defense:

Front Oncol 2021 Sep 14;11:746040. Potential Role of Exercise Induced Extracellular Vesicles in Prostate Cancer Suppression

Physical exercise - potentially influencing disease outcomes.

extracellular vesicles (EVs) have been recognized as a therapeutic target for cancer as tumor-derived EVs have the potential to promote metastatic capacity by transferring oncogenic proteins, integrins, and microRNAs to other cells and EVs are also involved in developing drug resistance.

Skeletal muscle is an endocrine organ, also releasing EVs into the circulation - levels of EV-containing factors have been shown to increase in response to exercise.

preclinical studies - tumor-suppressive effect of protein and microRNA contents in skeletal muscle-derived EVs in various cancers, including prostate cancer.

role of exercise in skeletal muscle-derived EVs circulating levels - the alteration of their contents, and the potential tumor-suppressive effect of skeletal muscle-derived EV contents in prostate cancer.

proposed mechanism of exercise in the uptake of skeletal muscle-derived EVs in prostate cancer.

Other physical training-immune related references, not PCa focused, not clinical, sorry.

2017 Cancer Immunology, Immunotherapy volume 66, pages667–671Exercise and cancer: from “healthy” to “therapeutic”?

Elife. 2020 Oct 23;9:e59996. Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

Exerc Immunol Rev . 2020;26:100-115.Benefits of exercise and immunotherapy in a murine model of human non-small-cell lung carcinoma

Oncotarget. 2020 Jan 28;11(4):452-461. Exercise reduces immune suppression and breast cancer progression in a preclinical model

2021. European Journal of Applied Physiology volume 121, pages637–644 (2021) Acute exercise impacts AhR and PD-1 levels of CD8+ T-cells—Exploratory results from a randomized cross-over trial comparing endurance versus resistance exercise

[Hidden in reply to Heilung18-Gesund]

Awesome info. Thanks!

[fmenninger]

is there any data to show that obese men, not rats or mice, die signficantly earlier than skinny men with aPCA?

[Hidden in reply to fmenninger]

I posted it above just before I saw your question.

I did find one study that showed that obesity extended lifespan. I suspect that this is true in the end-game. The extra fat stores are going to stave off cachexia.

Almost every study that I have looked at concludes exactly the opposite though. Obesity is bad for us.

The graphic is for overall survival and not cancer-specific but cancer survival has similar results.

Exercise vs. mortality J curves

[Hidden in reply to Hidden]

Could another factor be that most obese men take metformin which has been cited as something that inhibits or slows down prostate cancer progression?

[Hidden in reply to Hidden]

Could be. I don't recall if the authors went into that level of depth. The study conclusion was such an anomaly though that I discarded it.

[London441 in reply to fmenninger]

Obese vs skinny…I’ll take neither thanks.

[Hidden in reply to London441]

If I had to go with one I'd go with skinny, hands-down. Right now I'm young enough and healthy enough to be able to choose athletic.

When I did ADT I made it a point not to gain fat. I ended up dropping 8% of my bodyfat and sacrificed almost all of my muscle. That sucked but I gained back the muscle (and unfortunately most of the fat).

[Hidden]

The first thing my naturalpathic oncologist had me do was to drop all sugars , no animal proteins or dairy . A plant based diet . 7 yrs of this for me . 61/2 yrs no signs of pc . I cheat once in awhile now . Two scoops of chocolate chip , but my fist three years not a drop . Good luck .

[Hidden in reply to Hidden]

Yikes. That's a very disciplined life you are living. I don't think I could do it. And you do that on top of cannabis munchies too? Do you take B12 supplement since you aren't getting that from meat?

[ARIES29]

Great video thanks for sharing & how true! I gota loose 15kg now & I hope my doc will prescribe a new drug called Ozempic, my daughter lost 25 kg with that.

[Hidden in reply to ARIES29]

You're welcome.

You might want to ask your MO about Ozempic. It increases insulin and that might not be good for PCa.

Semaglutide, sold under the brand name Ozempic among others, is an antidiabetic medication used for the treatment of type 2 diabetes and long-term weight management. Semaglutide acts like human glucagon-like peptide-1 in that it increases insulin secretion, thereby increasing sugar metabolism. Wikipedia

[ARIES29]

Hmm, food for thought. Thanks for that & I dont like that increase of insulin report. It seems I would be better off not because it is very expensive anyway. Just go for fast off & on type practice.

[Hidden in reply to ARIES29]

Yeah. So complicated. Is having an artificially induced insulin spike clearing out sugar, with resulting fat loss, good or bad?

I agree though, better safe than sorry. There is some evidence behind fasting. I'm planning on talking to my MO about it but her comments in previous meetings make me think that she might acknowledge a possible benefit of fasting. The downside is that you get stinkin' hungry! I can easily fast for 24 hours (who can't). But 2+ days isn't fun for me.

I can do time-restricted feeding or even OMAD (one meal a day) till the cows come home and they seem to work ok (likely just the reduction of calories consumed).

[London441 in reply to Hidden]

Thanks for all of this. There is more coming out all the time as you know. The combination of exercise and clean diet/caloric restriction is the actual ‘magic bullet’ that is deemed not to exist.

And yes of course if we employ these we die anyway, and sometimes of pca. But it takes a lot longer, and we have vastly better QOL along the way.

[Hidden in reply to London441]

I had RP in 2018 and Mayo gave me 3 months before I was in the hospital again.

Hasn't happened and I think it is likely that one of the reasons why is that I workout like a beast and eat clean.

The potential upside is that I feel better and, as you said, cancer progresses slower.

The potential downside is that I feel better.

[London441 in reply to Hidden]

Feeling better is both a downside and a upside?

[Hidden in reply to London441]

In other words, it is a win/win.Best case it slows the beast and makes me a beast.

Worst case it makes me a beast (but doesn't slow the PCa beast).

[ARIES29 in reply to Hidden]

I agree, 1 meal a day has worked for me & I think going off food for more than 24 or 48hrs could be harmful. I have tried a product called Garcinia Max, 1 capsule with meals, it reduced appetite for me.

[Hidden in reply to ARIES29]

I also take some HCA (garcinia). Research is somewhat speculative but something has worked for me when I take:1400 mg garcinia, 5-10 mg yohimbine, 20 mg synephrine, 100 mg caffeine. I've tried taking caffeine alone but something else seems to be helping. I wouldn't swear to it though.

[ARIES29 in reply to Hidden]

My Garcinia is 3.75g & 3 times a day but I only take 1 every other day & it works for me. Another one is black Chia seeds, sprinkle on toast or over food, no taste & reduces hunger therefore weight.

[subliminaldood]

Any thoughts on fish? Salmon in particular?

[Hidden in reply to subliminaldood]

As I am typing this I'm cooking 7.5 ounces.Salmon might be heart-healthy.

Whether this study is correct or not, I like salmon and pacific wild-caught is fairly clean.

pubmed.ncbi.nlm.nih.gov/170...

"Eating fatty fish (e.g., salmon-type fish) once or more per week, compared to never, was associated with reduced risk of prostate cancer (OR: 0.57, 95% CI: 0.43-0.76). The OR comparing the highest to the lowest quartile of marine fatty acids intake was 0.70 (95% CI: 0.51-0.97). We found a significant interaction (p < 0.001) between salmon-type fish intake and a SNP in the COX-2 gene (rs5275: +6365 T/C), but not with the 4 other SNPs examined. We found strong inverse associations with increasing intake of salmon-type fish among carriers of the variant allele (OR for once per week or more vs. never = 0.28, 95% CI: 0.18-0.45; p(trend) < 0.01), but no association among carriers of the more common allele. Frequent consumption of fatty fish and marine fatty acids appears to reduce the risk of prostate cancer, and this association is modified by genetic variation in the COX-2 gene."

[Islandboy2021 in reply to subliminaldood]

I did vegan with wild salmon. Not sure how you can get enough clean protein being a true vegan. I have recently started adding some meat to my diet. After awhile you get sick of your diet and find it difficult to maintain it.

[Hidden in reply to Islandboy2021]

I mostly eat fruit, grains, nuts, edamame, and some veggies. I add some salmon a few times a week and eat lots of egg whites.

It's hard to get enough protein from a vegan diet. Edamame is an excellent source but lots of people banish it from their diets (the evidence is mixed, and I control my hormones exogenously and with drugs, so I decided to pig out on edamame - I find edamame pasta with lots of tomato pasta very good).