Hi all. My father is 2,5 years with stage 4, bone mets (some in pelvis zone, around 7 in ribs, spine, shoulders). After docetaxel in the very beginning psa dropped from 900 to 1,5. In 2,5 years there is a slight growth - 1,5-1,7, now 2,1. Scans are stable. Is this a dangerous trend and time to switch to arbiraterone? Or it is still stable? He is going to scans in 2 weeks
Psa slow increase: Hi all. My father is... - Advanced Prostate...
Psa slow increase
![Ilya profile image](https://images.hu-production.be/avatars/510e43f621af48008ccb53ec23a9ff12_small@2x_100x100.jpg)
![Ilya profile image](https://images.hu-production.be/avatars/510e43f621af48008ccb53ec23a9ff12_small@2x_100x100.jpg)
He's had docetaxel, what else is he on.... you say switch to arbiraterone from what??? His scans clear is a good sign. PSA slowly rising does mean darned old aPca is still hiding in there somewhere...
Great response to docetaxel! If scans show progression, try abiraterone, perhaps with Xofigo.
His PSA is stable around 2 if you round numbers. If there is radiological progression of the cancer abiraterone or other of the new anti androgen, plus Provenge may be some of the options to consider
Means he can still be hormone sensitive?
Sure he does. I mean what is the upward trend like to know if he is resistant? Plus 10?
I think radiographic progression is the best indicator the cancer has advanced and become castration resistant. If there are 3 or more sequential increases of the PSA they should do the scans and see if there is progression fo the cancer. The PSADT is also important if there is a short PSADT < 10 months they should do the scans.
Usually the upward trend would be 3 consecutive rises while on second ADT drug such as Abiraterone or xtandi before hormone resistant. He has lots of treatment options available.. and yes, probably still hormone sensitive.
There are lots of ADT drugs he could move on to.