In reading an article about Androgens, so I could understand how Xtandi works, I found this in that artical....
Although it’s not an androgen, someone may choose to have their SHBG levels tested if they’re worried about high androgen levels. As mentioned above, SHBG binds to testosterone. Sometimes high testosterone levels are not caused by an increase in testosterone production, but decreased levels of SHBG (2,9).
interesting
I wonder if this good could be a reason why some guys Spike on T when introduced to a new therapy????
T spikes at the start of GnRH agonist therapy because that's what a GnRH agonist is. An anti-androgen taken at the same time prevents the excess T from activating androgen receptors.When the pituitary senses the high T level, it shuts off all T production. GnRH antagonists (Firmagon, Orgovyx) directly shuts off T production.
Xtandi blocks the androgen receptor and prevents it from descending into the nucleus. T increases because it can't bind to androgen receptors and accumulates in the blood. But Lupron prevents T from being produced.
Free T is the unbound (by SHBG) T. But it is not an issue when T<30.
Wow, Well put, you are on it Tall_Allen, that’s what I got out of my 3 hours of study on this subject. Your a wealth of knowledge. Thanks for all your help
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