A-Fib & Cancer

[pjoshea13]

New study below [1].

Odd associations:

"In patients age <80 years, AF has significant association with lung cancer and multiple myeloma, whereas in patients age >80 years, it has significant association with non-Hodgkin lymphoma and prostate cancer. In patients age <80 years, increased mortality was seen in AF with lung cancer and in patients age >80 years, increased mortality was seen in those with AF and prostate cancer."

Background:

Studies have shown that the incidence of atrial fibrillation (AF) in cancer is most likely due to the presence of inflammatory markers. The purpose of our study is to determine the association of AF with different cancer subtypes and its impact on in-hospital outcomes.

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/346...

J Arrhythm

. 2021 Jul 17;37(5):1205-1214. doi: 10.1002/joa3.12589. eCollection 2021 Oct.

Association of atrial fibrillation and various cancer subtypes

Muhammad Zubair Khan 1 , Ashwani Gupta 2 , Kirtenkumar Patel 1 , Aida Abraham 1 , Sona Franklin 1 , Do Young Kim 1 , Krunalkumar Patel 1 , Ishtiaq Hussian 3 , Muhammad Samsoor Zarak 1 , Vincent Figueredo 2 , Steven Kutalek 2

Affiliations collapse

Affiliations

1 Department of Internal Medicine St. Mary Medical Center Langhorne PA USA.

2 Department of Cardiology St. Mary Medical Center Langhorne PA USA.

3 Department of Internal Medicine Cleveland Clinic Weston FL USA.

PMID: 34621418 PMCID: PMC8485786 DOI: 10.1002/joa3.12589

Abstract

Background: Studies have shown that the incidence of atrial fibrillation (AF) in cancer is most likely due to the presence of inflammatory markers. The purpose of our study is to determine the association of AF with different cancer subtypes and its impact on in-hospital outcomes.

Methods: Data were obtained from the National Inpatient Sample database between 2005 and 2015. Patients with various cancers and AF were studied. ICD-9-CM codes were utilized to verify variables. Patients were divided into three age groups: Group 1 (age < 65 years), Group 2 (age 65-80 years), and Group 3 (age > 80 years). Statistical analysis was performed using Pearson chi-square and binary logistic regression analysis to determine the association of individual cancers with AF.

Results: The prevalence of AF was 14.6% among total study patients (n = 46 030 380). After adjusting for confounding variables through multivariate regression analysis, AF showed significant association in Group 1 with lung cancer (odds ratio, OR = 1.92), multiple myeloma (OR = 1.59), non-Hodgkin lymphoma (OR = 1.55), respiratory cancer (OR = 1.55), prostate cancer (OR = 1.20), leukemia (OR = 1.12), and Hodgkin's lymphoma (OR = 1.03). In Group 2, the association of AF with multiple myeloma (1.21), lung cancer (OR = 1.15), Hodgkin lymphoma (OR = 1.15), non-Hodgkin lymphoma (OR = 1.12), respiratory cancer (OR = 1.08), prostate cancer (OR = 1.06), leukemia (OR = 1.14), and colon cancer (OR = 1.01) were significant. In Group 3, AF showed significant association with non-Hodgkin lymphoma (OR = 1.06), prostate (OR = 1.03), leukemia (OR = 1.03), Hodgkin's lymphoma (OR = 1.02), multiple myeloma (OR = 1.01), colon cancer (OR = 1.01), and breast cancer (OR = 1.01). The highest mortality was found in lung cancer in age <80 and prostate cancer in age >80.

Conclusion: In patients age <80 years, AF has significant association with lung cancer and multiple myeloma, whereas in patients age >80 years, it has significant association with non-Hodgkin lymphoma and prostate cancer. In patients age <80 years, increased mortality was seen in AF with lung cancer and in patients age >80 years, increased mortality was seen in those with AF and prostate cancer.

Twitter abstract: In age <80, lung cancer and multiple myeloma have a strong association with AF while thyroid and pancreatic cancers have no association with AF at any age. In age greater than 80, NHL and prostate cancer have a significant association with AF.

Keywords: atrial fibrillation; cancers.

© 2021 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Heart Rhythm Society.

[depotdoug]

Wow, an interesting analogy with different types of Cancer and AFIB. I don't like that word AFIB only because I've been fighting addressing that cardiac electrical issue for the last 10.5yrs. But my PCa started way back in June 2005. I'm in the < 80 now 69,5yo group.I'm going to read these studies thouroughly today tonight. Thanks pjoshea13. We all need all the knowledge we can glean about our complex APCa and meds, treatments that also affect our other body med problems like Cardiac too.

Doug

[Shooter1 in reply to depotdoug]

I agree it's interesting, but at 71, I really don't think I will be around to see 80. I started my 10 yr survival plan 3 years ago planning to get to 78. Time will tell. I was surprised to get past 30 with all I have done.

[Bluebird11]

I was surprised to hear there is a connection between D3 and AFIB. I didn't believe it at first until I looked it up. Since D3 seems integral to our health- I really question this. The information wasn't only speaking about overdosing. I know people who take 5000 a day and 10,000 once a week. the 10,000 once could skip but the 5000 seems important. Jim's D3 was low and we got it up to a good number. He never had any AFib problems. My cousin discovered this within her own health problem. She can't take D3. Have you heard anything about this. It does seem odd to me. Thanks... btw, I won't stop taking it...