Sterol-O-Acyl transferase 1

[Garp41]

nature.com/articles/s41391-...

Sounds important, but not sure what to do about it.

Doug

[pjoshea13]

"Potential confounders such as statin use ... but also follow-up treatment were unavailable which is expected to have varied over the relatively long recruitment period."

That was the only reference to statins in the full text. Considering that STOAT1 acts on cholesterol, I would have thought there would be some interest in cholesterol status & statin use.

-Patrick

[Spyder54]

“ConclusionOur results clearly show a high prognostic value of SOAT1 protein expression in high risk PCa patients which helps to identify a subgroup of high risk PCa patients rather likely to experience BCR. SOAT1 expression may be associated with increased cholesterol metabolism and potentially androgen signaling in PCa. Patients with high SOAT1 expression might be good candidates for pharmacological SOAT1 inhibition. SOAT1 inhibitors have been clinically developed and may be repurposed for PCa treatment.”

Mike

[Spyder54 in reply to Spyder54]

BCR:Biochemical Recurrence for us less informed