Association between vitamin D deficiency and prostate cancer: Prospective case-control study
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Ghanshyam Kumawat, Vijay Chaudhary, Anurag Garg, ...
First Published March 31, 2021 Research Article
doi.org/10.1177/20514158219...
Article information
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Abstract
Objective:
We aimed to find out the association of low serum vitamin D levels with the incidence of prostate cancer through a prospective case-control study.
Material and methods:
This study was carried out in the tertiary care hospital (India). All newly diagnosed patients of prostate cancer and age-matched controls were included. Serum vitamin D levels were measured in all of them. Vitamin D status (ng/mL) was classified as severe deficiency <10, moderate deficiency 10–<30, normal 30–100, and toxicity >100. Normality of the data was tested by the Kolmogorov–Smirnov test, statistical analysis was done with Statistical Package for the Social Sciences version 26.0, p-value of <0.05 was considered significant.
Results:
In our study, 320 cases and 320 controls were included. The mean vitamin D levels in cases and controls were 15.71 ± 6.5 (ng/mL) and 17.63 ± 4.54 (ng/mL), respectively, (p-Value <0.01). Patients with severe vitamin D deficiency (73.58%) had a Gleason score ⩾8 on biopsy and 79.24% of them had a serum prostate specific antigen (PSA) level >20 ng/mL.
Conclusion:
We had concluded that there was no significant association between vitamin D deficiency and increased risk of prostate cancer, although patients with higher-grade prostate cancer with higher PSA level had severe vitamin D deficiency.
Level of evidence:
Not applicable for this multicentre audit.
Yet another major study proves no causal connection between Vitamin D and prostate cancer
