Protein study

[TheTopBanana]

Hello,

I got this article from MaleCare-newsletter. Besides the depressing survival rate (I wish not every piece on aPC started that way) is this in your opinions interesting?

eurekalert.org/pub_releases...

[pjoshea13]

Hi TB,

It's true that mPCa survival stats are not ideal. But there are far worse cancers. And in this group, you will find men who have been living with mPCa for many years.

'Boilerplate' wording in mPCa studies usually make it sound as though the glass is nowhere near half-full. Nordic men and their daughters should avoid such studies, IMO.

The news on glypican-1 is interesting. I doubt that many here have given it much thought over the years. A 2013 Russian study [1] looked at proteoglycans (glypican-1, perlecan, syndecan-1, aggrecan, versican, NG2, brevican, decorin, and lumican):

"In normal human prostate tissue ... glypican-1 {was} expressed mainly by epithelial cells.

"In prostate tumours, complex changes in proteoglycans occur, with a common trend towards ..., overall increase of ... glypican-1 expression in tumour stroma along with its disappearance in tumour epithelial cells ..."

i.e. it disappears from PCa (epithelial) cells (along with many other proteins.)

However, later studies say that glypican-1 is actually over-expressed in tumors.

There followed some Australian interest in Glypican-1 as a biomarker for PCa.

In 2019, from the Athens, Georgia, U.S. team [2]:

"Paradoxical Role of Glypican-1 in Prostate Cancer Cell and Tumor Growth"

"We observed high expression of GPC-1 in more aggressive prostate cancer cell lines such as PC-3 and DU-145. While inhibition of GPC-1 expression in PC-3 cells decreased cell growth and migration in vitro, it surprisingly increased cell proliferation and migration in DU-145 cells, suggesting that the role of GPC-1 is cell type-dependent. Further, GPC-1 inhibition increased PC-3 tumor size in NCr nude mice xenografts. We hypothesized that the discrepancy between the in vitro and in vivo data is mediated by stromal cells in the tumor microenvironment."

Way too complicated for me.

Currently in the Wiikipedia page:

"In 2015 it was reported that the presence of this protein in exosomes in patients' blood is able to detect early pancreatic cancer with absolute specificity and sensitivity. However this conclusion is disputed. and in more recent overviews of potential markers for pancreatic cancer, Glypican 1 is not mentioned."

No mention of other cancers.

Apparently, not ready for prime time.

-Patrick

[1] ncbi.nlm.nih.gov/pmc/articl...

[2] pubmed.ncbi.nlm.nih.gov/313...

[cigafred in reply to pjoshea13]

Patrick,"Nordic men and their daughters should avoid such studies, IMO." I am probably missing something obvious, but why "Nordic"? [Daughter's partner/father of granddaughter is Nordic and his father has PC].

[TheTopBanana in reply to cigafred]

I’m Swedish so I think it was only a joke on that!

[cigafred in reply to TheTopBanana]

I am used to having trouble keeping up with Patrick's scientific explanations. Now I can't even keep up with his jokes!

[pjoshea13 in reply to cigafred]

Apologies! But both TB & her father have been going through a dark time of anxiety. A feeling that they should be doing more, except that he is doing very well after having oligometastatic PCa radiated. The curse of continous research is that one is forever being told that mPCa is fatal. I prefer to look at it as a challenging chronic condition.

Today in Stockholm the sun rose at 3:31 am & will set at 10:06 pm. A day to forget about research. A day to embrace life. IMO

-Patrick

[monte1111 in reply to cigafred]

That made me laugh. My mother was Swedish and father was Scotch/Irish. The lands of Ice and Fire.

[Hidden]

We already know the stats are bad . Personally I feel that if I buy into them ,then I’ll fall in line .. my uro told me 24 months with adt and 12 months Chemo . He was wrong . Glad I didn’t listen to the bs . Over six years later I’m still here with no t and no signs of pc . Will I live forever? HELL no. We all will suffer if we are to survive with this disease . You know that . After all , you are TheTopBanana!

[monte1111]

I should be called TheBottomBanana. Don't know much. The stats are certainly outdated. I had a back fracture, T12 disk compression. 5 year survival with skeletal event is 1%. If I make it 9 more months, I'll have made it 5 years since diagnosis, with a prognosis of 1 and a half to 2 and a half years. Lupron, chemo, Xtandi and Xgeva. Also Celecoxib (per Tall_Allen's mention of study), and Gabapentin for Neuropathy. Tramadol for back pain. Holding steady at 0.1 Psa. No bone scan in a year. I will be irked if I have a heart attack and don't make the 5 years. Although I am a Godless man, I pray for those whose APC had a short, steady conclusion. So much seems to be just a flip of the coin. Wishing you and dad the best. (My mother said ja for yes. Didn't notice it until I was in my 50's. No was still no. )