CNN article published today:
Cancer:
Another obvious use for mRNA technology is to fight cancer. The human body fights off cancer every day, and using mRNA could help it do so even better.
"You can use it to have your body produce a beneficial molecule," McLellan said.
Different tumor cell types have various, recognizable structures on the outside that the immune system can recognize. "You can imagine being able to inject someone with an mRNA that encodes an antibody that specifically targets that receptor," McLellan said.
Moderna -- a company formed specially to develop mRNA technology -- is working on personalized cancer vaccines.
Single Pfizer vaccine shot provides strong protection for those who've had Covid-19, UK studies suggest
Single Pfizer vaccine shot provides strong protection for those who've had Covid-19, UK studies suggest
"We identify mutations found on a patient's cancer cells," the company says on its website. Computer algorithms predict the 20 most common mutations. "We then create a vaccine that encodes for each of these mutations and load them onto a single mRNA molecule," Moderna says. That's injected into the patient to try to help orchestrate a better immune response against the tumors.
This is early, Phase 1 clinical research.
BioNTech founders Ugur Sahin and Ozlem Tureci also had cancer vaccines in mind from the beginning. The company has eight potential cancer treatments in human trials. "While we believe our approach is broadly applicable across a number of therapeutic areas, our most advanced programs are focused on oncology, where we have treated over 250 patients across 17 tumor types to date," the company says on its website.