Nivolumab + Ipilimumab for MCRPC

[ronton2]

How are these drugs administered? Is a genetic component more reactive to this therapy. Does this show promise?

[Tall_Allen]

They are both administered iv. The combination was found to be highly toxic as tested. It had some but not much activity- some response in 10% in patients who'd already had chemo,and in 26% of patients who were chemo-naive. Response was better among patients who had higher levels of PD-L1 (≥1%), DNA damage repair defects(DDR), homologous recombination deficiency (HRD), or above-median tumor mutational burden (TMB). They stopped the trial and used more nivo and less ipi. We shall see if that helps.

meetinglibrary.asco.org/rec...

medpagetoday.com/meetingcov...

[addicted2cycling]

As I've mentioned, the one time Opdivo + Yervoy + Keytruda combo was in situ 7 months following the hemi-cryoablation of the GL10 right half of prostate in Dec. 2015.